An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics

An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics

Standard high throughput screening projects using automated patch-clamp instruments often fail to grasp essential details of the mechanism of action, such as binding/unbinding dynamics and modulation of gating. In this study, we aim to demonstrate that depth of analysis can be combined with acceptab...

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Bibliographic Details
Main Authors: Peter Lukacs, Krisztina Pesti, Mátyás C. Földi, Katalin Zboray, Adam V. Toth, Gábor Papp, Arpad Mike
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
automated patch-clamp
sodium channel inhibitor
binding kinetics
epilepsy
pain
neuromuscular disorders
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.738260/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.738260/full

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