Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women
Risk factors for the different human papillomavirus (HPV) genotypes are not well understood, although the risk of cancer is known to vary among them. Our aim was to evaluate the association of diverse behavioral and reproductive factors with genotype-specific HPV prevalence among 879 unvaccinated wo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/4/750 |
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| author | Laura Bergqvist Ilkka Kalliala Karoliina Aro Eeva Auvinen Maija Jakobsson Mari Kiviharju Seppo Virtanen Joakim Dillner Pekka Nieminen Karolina Louvanto |
| author_facet | Laura Bergqvist Ilkka Kalliala Karoliina Aro Eeva Auvinen Maija Jakobsson Mari Kiviharju Seppo Virtanen Joakim Dillner Pekka Nieminen Karolina Louvanto |
| author_sort | Laura Bergqvist |
| collection | DOAJ |
| description | Risk factors for the different human papillomavirus (HPV) genotypes are not well understood, although the risk of cancer is known to vary among them. Our aim was to evaluate the association of diverse behavioral and reproductive factors with genotype-specific HPV prevalence among 879 unvaccinated women aged 18–75 years referred to the colposcopy clinic at Helsinki University Hospital in Finland. Cervical swabs for HPV genotyping were collected in the first visit and assessed for 34 high-risk (hr) and low-risk (lr) HPV genotypes. Participants completed a questionnaire on behavioral, reproductive, and lifestyle factors. Differences in genotype-specific HPV prevalence were analyzed overall and in age groups using binary logistic regression. Smoking was associated with higher prevalence in HPV16 compared with other hrHPV genotypes together with decreasing age, being highest among younger women <30 years old, odds ratio (OR) 3.74 (95% CI 1.42–9.88). The later the sexual debut, the more it seemed to protect from HPV16 infection. The best protection was achieved when the sexual debut took place at >20 years of age, with an OR of 0.43 (95% CI 0.23–0.83). This association was not seen with other hrHPV genotypes. Methods of contraception seemed not to have an effect on hrHPV positivity, regardless of the HPV genotype. The genotype specific hrHPV prevalence differs, depending on behavioral factors, especially among younger women referred to colposcopy. |
| first_indexed | 2024-03-10T12:38:51Z |
| format | Article |
| id | doaj.art-a466ee173a554314982d67d762726568 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T12:38:51Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-a466ee173a554314982d67d7627265682023-11-21T14:03:32ZengMDPI AGMicroorganisms2076-26072021-04-019475010.3390/microorganisms9040750Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young WomenLaura Bergqvist0Ilkka Kalliala1Karoliina Aro2Eeva Auvinen3Maija Jakobsson4Mari Kiviharju5Seppo Virtanen6Joakim Dillner7Pekka Nieminen8Karolina Louvanto9Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, FinlandDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, FinlandDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, FinlandDepartment of Virology, University of Helsinki and Helsinki University Hospital, 00014 Helsinki, FinlandDepartment of Obstetrics and Gynecology, Hyvinkää Hospital, HUCH and University of Helsinki, 05850 Hyvinkää, FinlandDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, FinlandDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, FinlandDepartment of Laboratory Medicine, Karolinska Institute, SE-171 77 Stockholm, SwedenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, 00029 Helsinki, FinlandDepartment of Obstetrics and Gynecology, Tampere University Hospital and Tampere University, 33100 Tampere, FinlandRisk factors for the different human papillomavirus (HPV) genotypes are not well understood, although the risk of cancer is known to vary among them. Our aim was to evaluate the association of diverse behavioral and reproductive factors with genotype-specific HPV prevalence among 879 unvaccinated women aged 18–75 years referred to the colposcopy clinic at Helsinki University Hospital in Finland. Cervical swabs for HPV genotyping were collected in the first visit and assessed for 34 high-risk (hr) and low-risk (lr) HPV genotypes. Participants completed a questionnaire on behavioral, reproductive, and lifestyle factors. Differences in genotype-specific HPV prevalence were analyzed overall and in age groups using binary logistic regression. Smoking was associated with higher prevalence in HPV16 compared with other hrHPV genotypes together with decreasing age, being highest among younger women <30 years old, odds ratio (OR) 3.74 (95% CI 1.42–9.88). The later the sexual debut, the more it seemed to protect from HPV16 infection. The best protection was achieved when the sexual debut took place at >20 years of age, with an OR of 0.43 (95% CI 0.23–0.83). This association was not seen with other hrHPV genotypes. Methods of contraception seemed not to have an effect on hrHPV positivity, regardless of the HPV genotype. The genotype specific hrHPV prevalence differs, depending on behavioral factors, especially among younger women referred to colposcopy.https://www.mdpi.com/2076-2607/9/4/750colposcopyhuman papillomavirus (HPV)risk factorquestionnairehigh-risk human papillomavirus (HPV) |
| spellingShingle | Laura Bergqvist Ilkka Kalliala Karoliina Aro Eeva Auvinen Maija Jakobsson Mari Kiviharju Seppo Virtanen Joakim Dillner Pekka Nieminen Karolina Louvanto Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women Microorganisms colposcopy human papillomavirus (HPV) risk factor questionnaire high-risk human papillomavirus (HPV) |
| title | Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women |
| title_full | Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women |
| title_fullStr | Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women |
| title_full_unstemmed | Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women |
| title_short | Distribution of HPV Genotypes Differs Depending on Behavioural Factors among Young Women |
| title_sort | distribution of hpv genotypes differs depending on behavioural factors among young women |
| topic | colposcopy human papillomavirus (HPV) risk factor questionnaire high-risk human papillomavirus (HPV) |
| url | https://www.mdpi.com/2076-2607/9/4/750 |
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