Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention
Myopia is a globally emerging concern accompanied by multiple medical and socio-economic burdens with no well-established causal treatment to control thus far. The study of the genomics and transcriptomics of myopia treatment is crucial to delineate disease pathways and provide valuable insights for...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/3/494 |
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| author | Liqin Jiang Dong Xuan Goh James Hao Zhong Koh Xavier Chan Noel A. Brennan Veluchamy Amutha Barathi Quan V. Hoang |
| author_facet | Liqin Jiang Dong Xuan Goh James Hao Zhong Koh Xavier Chan Noel A. Brennan Veluchamy Amutha Barathi Quan V. Hoang |
| author_sort | Liqin Jiang |
| collection | DOAJ |
| description | Myopia is a globally emerging concern accompanied by multiple medical and socio-economic burdens with no well-established causal treatment to control thus far. The study of the genomics and transcriptomics of myopia treatment is crucial to delineate disease pathways and provide valuable insights for the design of precise and effective therapeutics. A strong understanding of altered biochemical pathways and underlying pathogenesis leading to myopia may facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and therapeutic measures. In this review, we summarize current data about the genomics and transcriptomics of myopia in human and animal models. We also discuss the potential applicability of these findings to precision medicine for myopia treatment. |
| first_indexed | 2024-03-11T06:52:47Z |
| format | Article |
| id | doaj.art-a4676dd42049490dae6eaafc5470279f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T06:52:47Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-a4676dd42049490dae6eaafc5470279f2023-11-17T09:52:05ZengMDPI AGBiomolecules2218-273X2023-03-0113349410.3390/biom13030494Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or PreventionLiqin Jiang0Dong Xuan Goh1James Hao Zhong Koh2Xavier Chan3Noel A. Brennan4Veluchamy Amutha Barathi5Quan V. Hoang6Singapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, SingaporeJohnson & Johnson Vision, Jacksonville, FL 32256, USASingapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, SingaporeSingapore Eye Research Institute, Singapore National Eye Centre, Eye ACP Duke-NUS Medical School, Singapore 169856, SingaporeMyopia is a globally emerging concern accompanied by multiple medical and socio-economic burdens with no well-established causal treatment to control thus far. The study of the genomics and transcriptomics of myopia treatment is crucial to delineate disease pathways and provide valuable insights for the design of precise and effective therapeutics. A strong understanding of altered biochemical pathways and underlying pathogenesis leading to myopia may facilitate early diagnosis and treatment of myopia, ultimately leading to the development of more effective preventive and therapeutic measures. In this review, we summarize current data about the genomics and transcriptomics of myopia in human and animal models. We also discuss the potential applicability of these findings to precision medicine for myopia treatment.https://www.mdpi.com/2218-273X/13/3/494MyopiamoleculargenomicsGWAStranscriptomicsanimal models |
| spellingShingle | Liqin Jiang Dong Xuan Goh James Hao Zhong Koh Xavier Chan Noel A. Brennan Veluchamy Amutha Barathi Quan V. Hoang Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention Biomolecules Myopia molecular genomics GWAS transcriptomics animal models |
| title | Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention |
| title_full | Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention |
| title_fullStr | Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention |
| title_full_unstemmed | Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention |
| title_short | Applications of Genomics and Transcriptomics in Precision Medicine for Myopia Control or Prevention |
| title_sort | applications of genomics and transcriptomics in precision medicine for myopia control or prevention |
| topic | Myopia molecular genomics GWAS transcriptomics animal models |
| url | https://www.mdpi.com/2218-273X/13/3/494 |
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