Tendon vasculature in health and disease.
Tendons represent a bradytrophic tissue which is poorly vascularized and, compared to bone or skin, heal poorly. Usually, a vascularized connective scar tissue with inferior functional properties forms at the injury site. Whether the increased vascularization is the root cause of tissue impairments...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00330/full |
| _version_ | 1819143010881896448 |
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| author | Herbert eTempfer Herbert eTempfer Andreas eTraweger Andreas eTraweger |
| author_facet | Herbert eTempfer Herbert eTempfer Andreas eTraweger Andreas eTraweger |
| author_sort | Herbert eTempfer |
| collection | DOAJ |
| description | Tendons represent a bradytrophic tissue which is poorly vascularized and, compared to bone or skin, heal poorly. Usually, a vascularized connective scar tissue with inferior functional properties forms at the injury site. Whether the increased vascularization is the root cause of tissue impairments such as loss of collagen fibre orientation, ectopic formation of bone, fat or cartilage, or is a consequence of these pathological changes remains unclear. This review provides an overview of the role of tendon vasculature in healthy and chronically diseased tendon tissue as well as its relevance for tendon repair. Further, the nature and the role of perivascular tendon stem/progenitor cells residing in the vascular niche will be discussed and compared to multipotent stromal cells in other tissues. |
| first_indexed | 2024-12-22T12:19:27Z |
| format | Article |
| id | doaj.art-a469fe8cc79847bb8b94c451724dbb2d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-22T12:19:27Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-a469fe8cc79847bb8b94c451724dbb2d2022-12-21T18:26:03ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2015-11-01610.3389/fphys.2015.00330163621Tendon vasculature in health and disease.Herbert eTempfer0Herbert eTempfer1Andreas eTraweger2Andreas eTraweger3Paracelsus Medical University, Spinal Cord Injury and Tissue Regeneration Center SazburgAustrian Cluster for Tissue RegenerationParacelsus Medical University, Spinal Cord Injury and Tissue Regeneration Center SazburgAustrian Cluster for Tissue RegenerationTendons represent a bradytrophic tissue which is poorly vascularized and, compared to bone or skin, heal poorly. Usually, a vascularized connective scar tissue with inferior functional properties forms at the injury site. Whether the increased vascularization is the root cause of tissue impairments such as loss of collagen fibre orientation, ectopic formation of bone, fat or cartilage, or is a consequence of these pathological changes remains unclear. This review provides an overview of the role of tendon vasculature in healthy and chronically diseased tendon tissue as well as its relevance for tendon repair. Further, the nature and the role of perivascular tendon stem/progenitor cells residing in the vascular niche will be discussed and compared to multipotent stromal cells in other tissues.http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00330/fullTendinopathylymphaticstendon regenerationTendon vasculaturetendon stem/ progenitor cells |
| spellingShingle | Herbert eTempfer Herbert eTempfer Andreas eTraweger Andreas eTraweger Tendon vasculature in health and disease. Frontiers in Physiology Tendinopathy lymphatics tendon regeneration Tendon vasculature tendon stem/ progenitor cells |
| title | Tendon vasculature in health and disease. |
| title_full | Tendon vasculature in health and disease. |
| title_fullStr | Tendon vasculature in health and disease. |
| title_full_unstemmed | Tendon vasculature in health and disease. |
| title_short | Tendon vasculature in health and disease. |
| title_sort | tendon vasculature in health and disease |
| topic | Tendinopathy lymphatics tendon regeneration Tendon vasculature tendon stem/ progenitor cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00330/full |
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