Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells

Alpha7 Nicotinic Acetylcholine Receptor Mediates Nicotine-induced Apoptosis and Cell Cycle Arrest of Hepatocellular Carcinoma HepG2 Cells

Purpose: The cytotoxic properties upon treatment with nicotine have been reported in several studies, but the underlying mechanisms remain not fully defined. The alpha7 nicotinic acetylcholine receptor (α7nAChR) is one of the important nicotinic receptors, which nicotine partly by binding to this re...

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Bibliographic Details
Main Authors: Khalil Hajiasgharzadeh, Mohammad Hossein Somi, Behzad Mansoori, Mohammad Amin Doustvandi, Fatemeh Vahidian, Mohsen Alizadeh, Ahad Mokhtarzadeh, Dariush Shanehbandi, Behzad Baradaran
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2020-01-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
alpha7 nicotinic acetylcholine receptor
small interfering rna
nicotine
hepg2
apoptosis
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-27763

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