A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis

De novo purine nucleotide biosynthesis (DNPNB) consists of sequential reactions that are majorly conserved in living organisms. Several regulation events take place to maintain physiological concentrations of adenylate and guanylate nucleotides in cells and to fine-tune the production of purine nucl...

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Bibliographic Details
Main Authors:	Nour Ayoub, Antoine Gedeon, Hélène Munier-Lehmann
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Pharmacology
Subjects:	allostery antibacterial agents chemical compounds enzyme regulation IMP dehydrogenase nucleotide biosynthesis
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1329011/full

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