Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer

Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer

Abstract Background Human breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit (TDLU). This structure is endowed with its very own lobular fibroblasts representing one out of two steady-state fibroblast subtypes—the other b...

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Bibliographic Details
Main Authors: Mikkel Morsing Bagger, Jonas Sjölund, Jiyoung Kim, Katharina Theresa Kohler, René Villadsen, Abbas Jafari, Moustapha Kassem, Kristian Pietras, Lone Rønnov-Jessen, Ole William Petersen
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Cancer-associated fibroblast
Fibroblast
iCAF
myCAF
Cell line
Online Access:https://doi.org/10.1186/s13058-024-01763-3

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