Clinical features and toxicity of tuberculosis treatment in patients with cancer
Objectives. To assess the clinical and epidemiological characteristics of active tuberculosis in patients with malignancy and to assess the influence of TB treatment on cancer management at the National Institute of Neoplastic Diseases from 2008 to 2013. Materials and methods. Observational study of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Instituto Nacional de Salud
2015-06-01
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| Series: | Revista Peruana de Medicina Experimental y Salud Pública |
| Subjects: | |
| Online Access: | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1619 |
| _version_ | 1831648271153496064 |
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| author | Luis Cuéllar Carlos A. Castañeda Katerin Rojas Claudio Flores Ketty Dolores-Cerna Miluska Castillo William Vicente |
| author_facet | Luis Cuéllar Carlos A. Castañeda Katerin Rojas Claudio Flores Ketty Dolores-Cerna Miluska Castillo William Vicente |
| author_sort | Luis Cuéllar |
| collection | DOAJ |
| description | Objectives. To assess the clinical and epidemiological characteristics of active tuberculosis in patients with malignancy and to assess the influence of TB treatment on cancer management at the National Institute of Neoplastic Diseases from 2008 to 2013. Materials and methods. Observational study of TB cases diagnosed by positive sputum microscopy in patients with cancer. Clinical information, evolution, and pathologic information of neoplasia was reviewed. Results.76 cases of active tuberculosis after being diagnosed with cancer were found. The median age was 51.3 years. Median follow-up was 2.1 years. The most common cancers were acute lymphocytic leukemia (14.5%), for the hematologic cancers; and cancer of the cervix (14.5%), breast (10.5%), and gastric (7.9%) for non-hematological cancers. 27.6% of patients had recurrence of the tumor; TB diagnosis confounded the initial staging by 6.9% and was initially stated as cancer recurrence in 11.1% (breast and colon cancers). The diagnosis of tuberculosis delayed or influenced the dose reduction of the antineoplastic treatment in 11.1% of the cases (acute lymphocytic leukemia and non-Hodgkin lymphoma). 8.3% of patients had toxicity to the TB treatment. Conclusions. Cancer patients may have active tuberculosis infection. The interference effect of diagnosis and treatment of tuberculosis on the assessment of cancer and cancer treatment in our series is minimal. |
| first_indexed | 2024-12-19T14:28:53Z |
| format | Article |
| id | doaj.art-a46f6a4840854a1fa3069c55ce1ac54c |
| institution | Directory Open Access Journal |
| issn | 1726-4634 1726-4642 |
| language | Spanish |
| last_indexed | 2024-12-19T14:28:53Z |
| publishDate | 2015-06-01 |
| publisher | Instituto Nacional de Salud |
| record_format | Article |
| series | Revista Peruana de Medicina Experimental y Salud Pública |
| spelling | doaj.art-a46f6a4840854a1fa3069c55ce1ac54c2022-12-21T20:17:32ZspaInstituto Nacional de SaludRevista Peruana de Medicina Experimental y Salud Pública1726-46341726-46422015-06-0132227227710.17843/rpmesp.2015.322.16191601Clinical features and toxicity of tuberculosis treatment in patients with cancerLuis Cuéllar0Carlos A. Castañeda1Katerin Rojas2Claudio Flores3Ketty Dolores-Cerna4Miluska Castillo5William Vicente6Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Oncosalud/AUNA. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Instituto Nacional de Enfermedades Neoplásicas. Lima, Perú.Objectives. To assess the clinical and epidemiological characteristics of active tuberculosis in patients with malignancy and to assess the influence of TB treatment on cancer management at the National Institute of Neoplastic Diseases from 2008 to 2013. Materials and methods. Observational study of TB cases diagnosed by positive sputum microscopy in patients with cancer. Clinical information, evolution, and pathologic information of neoplasia was reviewed. Results.76 cases of active tuberculosis after being diagnosed with cancer were found. The median age was 51.3 years. Median follow-up was 2.1 years. The most common cancers were acute lymphocytic leukemia (14.5%), for the hematologic cancers; and cancer of the cervix (14.5%), breast (10.5%), and gastric (7.9%) for non-hematological cancers. 27.6% of patients had recurrence of the tumor; TB diagnosis confounded the initial staging by 6.9% and was initially stated as cancer recurrence in 11.1% (breast and colon cancers). The diagnosis of tuberculosis delayed or influenced the dose reduction of the antineoplastic treatment in 11.1% of the cases (acute lymphocytic leukemia and non-Hodgkin lymphoma). 8.3% of patients had toxicity to the TB treatment. Conclusions. Cancer patients may have active tuberculosis infection. The interference effect of diagnosis and treatment of tuberculosis on the assessment of cancer and cancer treatment in our series is minimal.https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1619tuberculosiscáncertoxicidadtratamiento |
| spellingShingle | Luis Cuéllar Carlos A. Castañeda Katerin Rojas Claudio Flores Ketty Dolores-Cerna Miluska Castillo William Vicente Clinical features and toxicity of tuberculosis treatment in patients with cancer Revista Peruana de Medicina Experimental y Salud Pública tuberculosis cáncer toxicidad tratamiento |
| title | Clinical features and toxicity of tuberculosis treatment in patients with cancer |
| title_full | Clinical features and toxicity of tuberculosis treatment in patients with cancer |
| title_fullStr | Clinical features and toxicity of tuberculosis treatment in patients with cancer |
| title_full_unstemmed | Clinical features and toxicity of tuberculosis treatment in patients with cancer |
| title_short | Clinical features and toxicity of tuberculosis treatment in patients with cancer |
| title_sort | clinical features and toxicity of tuberculosis treatment in patients with cancer |
| topic | tuberculosis cáncer toxicidad tratamiento |
| url | https://rpmesp.ins.gob.pe/index.php/rpmesp/article/view/1619 |
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