The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system
Data on patterns of weight change among adults with overweight or obesity are minimal. We aimed to examine patterns of weight change and associated hospitalizations in a large health system, and to develop a model to predict 2-year significant weight gain.Data from the Duke University Health System...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Preventive Medicine Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211335521003065 |
| _version_ | 1818460056022155264 |
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| author | Neha J. Pagidipati Matthew Phelan Courtney Page Megan Clowse Ricardo Henao Eric D. Peterson Benjamin A. Goldstein |
| author_facet | Neha J. Pagidipati Matthew Phelan Courtney Page Megan Clowse Ricardo Henao Eric D. Peterson Benjamin A. Goldstein |
| author_sort | Neha J. Pagidipati |
| collection | DOAJ |
| description | Data on patterns of weight change among adults with overweight or obesity are minimal. We aimed to examine patterns of weight change and associated hospitalizations in a large health system, and to develop a model to predict 2-year significant weight gain.Data from the Duke University Health System was abstracted from 1/1/13 to 12/31/16 on patients with BMI ≥ 25 kg/m2 in 2014. A regression model was developed to predict patients that would increase their weight by 10% within 2 years. We estimated the association between weight change category and all-cause hospitalization using Cox proportional hazards models.Of the 37,253 patients in our cohort, 59% had stable weight over 2 years, while 24% gained ≥ 5% weight and 17% lost ≥ 5% weight. Our predictive model had reasonable discriminatory capacity to predict which individuals would gain ≥ 10% weight over 2 years (AUC 0.73). Compared with stable weight, the risk of hospitalization was increased by 37% for individuals with > 10% weight loss [adj. HR (95% CI): 1.37 (1.25,1.5)], by 30% for those with > 10% weight gain [adj. HR (95% CI): 1.3 (1.19,1.42)], by 18% for those with 5–10% weight loss [adj. HR (95% CI): 1.18 (1.09,1.28)], and by 10% for those with 5–10% weight gain [adj. HR (95% CI): 1.1 (1.02,1.19)].In this examination of a large health system, significant weight gain or loss of > 10% was associated with increased all-cause hospitalization over 2 years compared with stable weight. This analysis adds to the increasing observational evidence that weight stability may be a key health driver. |
| first_indexed | 2024-12-14T23:24:10Z |
| format | Article |
| id | doaj.art-a46f90ca5e1748e6b9b763ce7ead3a5c |
| institution | Directory Open Access Journal |
| issn | 2211-3355 |
| language | English |
| last_indexed | 2024-12-14T23:24:10Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Preventive Medicine Reports |
| spelling | doaj.art-a46f90ca5e1748e6b9b763ce7ead3a5c2022-12-21T22:43:52ZengElsevierPreventive Medicine Reports2211-33552021-12-0124101615The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care systemNeha J. Pagidipati0Matthew Phelan1Courtney Page2Megan Clowse3Ricardo Henao4Eric D. Peterson5Benjamin A. Goldstein6Duke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USA; Corresponding author at: Duke Clinical Research Institute, 200 Morris Street, Durham, NC 27701, USA.Duke Clinical Research Institute, Durham, NC, USADuke Clinical Research Institute, Durham, NC, USADuke University School of Medicine, Durham, NC, USADuke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USAUniversity of Texas at Southwestern, Dallas, TX, USADuke University School of Medicine, Durham, NC, USA; Duke Clinical Research Institute, Durham, NC, USAData on patterns of weight change among adults with overweight or obesity are minimal. We aimed to examine patterns of weight change and associated hospitalizations in a large health system, and to develop a model to predict 2-year significant weight gain.Data from the Duke University Health System was abstracted from 1/1/13 to 12/31/16 on patients with BMI ≥ 25 kg/m2 in 2014. A regression model was developed to predict patients that would increase their weight by 10% within 2 years. We estimated the association between weight change category and all-cause hospitalization using Cox proportional hazards models.Of the 37,253 patients in our cohort, 59% had stable weight over 2 years, while 24% gained ≥ 5% weight and 17% lost ≥ 5% weight. Our predictive model had reasonable discriminatory capacity to predict which individuals would gain ≥ 10% weight over 2 years (AUC 0.73). Compared with stable weight, the risk of hospitalization was increased by 37% for individuals with > 10% weight loss [adj. HR (95% CI): 1.37 (1.25,1.5)], by 30% for those with > 10% weight gain [adj. HR (95% CI): 1.3 (1.19,1.42)], by 18% for those with 5–10% weight loss [adj. HR (95% CI): 1.18 (1.09,1.28)], and by 10% for those with 5–10% weight gain [adj. HR (95% CI): 1.1 (1.02,1.19)].In this examination of a large health system, significant weight gain or loss of > 10% was associated with increased all-cause hospitalization over 2 years compared with stable weight. This analysis adds to the increasing observational evidence that weight stability may be a key health driver.http://www.sciencedirect.com/science/article/pii/S2211335521003065ObesityWeight changeRisk prediction |
| spellingShingle | Neha J. Pagidipati Matthew Phelan Courtney Page Megan Clowse Ricardo Henao Eric D. Peterson Benjamin A. Goldstein The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system Preventive Medicine Reports Obesity Weight change Risk prediction |
| title | The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system |
| title_full | The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system |
| title_fullStr | The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system |
| title_full_unstemmed | The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system |
| title_short | The importance of weight stabilization amongst those with overweight or obesity: Results from a large health care system |
| title_sort | importance of weight stabilization amongst those with overweight or obesity results from a large health care system |
| topic | Obesity Weight change Risk prediction |
| url | http://www.sciencedirect.com/science/article/pii/S2211335521003065 |
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