Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays
Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal infection. The need for HIV-1 remission and cure a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/12/2608 |
| _version_ | 1827636594290458624 |
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| author | Priya Khetan Yufeng Liu Adit Dhummakupt Deborah Persaud |
| author_facet | Priya Khetan Yufeng Liu Adit Dhummakupt Deborah Persaud |
| author_sort | Priya Khetan |
| collection | DOAJ |
| description | Significant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal infection. The need for HIV-1 remission and cure arises due to the inability of ART to eradicate the major reservoir for HIV-1 in resting memory CD4+ T cells (the latent reservoir), and the strict adherence to lifelong treatment. To measure the efficacy of these cure interventions on reservoir size and to dissect reservoir dynamics, assays that are sensitive and specific to intact proviruses are critical. In this review, we provided a broad overview of some of the key interventions underway to purge the reservoir in adults living with HIV-1 and ones under study in pediatric populations to reduce and control the latent reservoir, primarily focusing on very early treatment in combination with broadly neutralizing antibodies. We also summarized assays currently in use to measure HIV-1 reservoirs and their feasibility and considerations for studies in children. |
| first_indexed | 2024-03-09T15:45:01Z |
| format | Article |
| id | doaj.art-a4704dfe381f43589c7ed19d80905de9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:45:01Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-a4704dfe381f43589c7ed19d80905de92023-11-24T18:36:27ZengMDPI AGViruses1999-49152022-11-011412260810.3390/v14122608Advances in Pediatric HIV-1 Cure Therapies and Reservoir AssaysPriya Khetan0Yufeng Liu1Adit Dhummakupt2Deborah Persaud3Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USAW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USADivision of Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USADivision of Infectious Diseases, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USASignificant advances in the field of HIV-1 therapeutics to achieve antiretroviral treatment (ART)-free remission and cure for persons living with HIV-1 are being made with the advent of broadly neutralizing antibodies and very early ART in perinatal infection. The need for HIV-1 remission and cure arises due to the inability of ART to eradicate the major reservoir for HIV-1 in resting memory CD4+ T cells (the latent reservoir), and the strict adherence to lifelong treatment. To measure the efficacy of these cure interventions on reservoir size and to dissect reservoir dynamics, assays that are sensitive and specific to intact proviruses are critical. In this review, we provided a broad overview of some of the key interventions underway to purge the reservoir in adults living with HIV-1 and ones under study in pediatric populations to reduce and control the latent reservoir, primarily focusing on very early treatment in combination with broadly neutralizing antibodies. We also summarized assays currently in use to measure HIV-1 reservoirs and their feasibility and considerations for studies in children.https://www.mdpi.com/1999-4915/14/12/2608cure strategiesreservoir assaysintact proviruspediatric HIV-1 infection |
| spellingShingle | Priya Khetan Yufeng Liu Adit Dhummakupt Deborah Persaud Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays Viruses cure strategies reservoir assays intact provirus pediatric HIV-1 infection |
| title | Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays |
| title_full | Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays |
| title_fullStr | Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays |
| title_full_unstemmed | Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays |
| title_short | Advances in Pediatric HIV-1 Cure Therapies and Reservoir Assays |
| title_sort | advances in pediatric hiv 1 cure therapies and reservoir assays |
| topic | cure strategies reservoir assays intact provirus pediatric HIV-1 infection |
| url | https://www.mdpi.com/1999-4915/14/12/2608 |
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