Peptidomimetic blockade of MYB in acute myeloid leukemia
MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.
Bibliographic Details
| Main Authors: |
Kavitha Ramaswamy,
Lauren Forbes,
Gerard Minuesa,
Tatyana Gindin,
Fiona Brown,
Michael G. Kharas,
Andrei V. Krivtsov,
Scott A. Armstrong,
Eric Still,
Elisa de Stanchina,
Birgit Knoechel,
Richard Koche,
Alex Kentsis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-02618-6
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