Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
<i>Saprochaete capitata</i> is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in tho...
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MDPI AG
2021-11-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/11/1289 |
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| author | Francesca Gurrieri Silvia Corbellini Giorgio Piccinelli Alessandro Turra Enrico Morello Michele Malagola Domenico Russo Arnaldo Caruso Maria Antonia De Francesco |
| author_facet | Francesca Gurrieri Silvia Corbellini Giorgio Piccinelli Alessandro Turra Enrico Morello Michele Malagola Domenico Russo Arnaldo Caruso Maria Antonia De Francesco |
| author_sort | Francesca Gurrieri |
| collection | DOAJ |
| description | <i>Saprochaete capitata</i> is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in those affected by acute leukemia. An important risk factor that predisposes to this infection is the profound neutropenia present in such immunocompromised patients. <i>Saprochaete</i> spp. were found resistant to both echinocandins and fluconazole so the treatment is often difficult. Here, we report two cases of sepsis in two patients with acute leukemia. All of them had fatal events, due to the worsening of their clinical condition. An early diagnosis and appropriate management of these pathogens is important in consideration of the poor prognosis associated to these fungal invasive infections. |
| first_indexed | 2024-03-10T05:00:24Z |
| format | Article |
| id | doaj.art-a4736dc4259944368711b7e55cdf010b |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T05:00:24Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
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| series | Vaccines |
| spelling | doaj.art-a4736dc4259944368711b7e55cdf010b2023-11-23T01:52:28ZengMDPI AGVaccines2076-393X2021-11-01911128910.3390/vaccines9111289Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological MalignanciesFrancesca Gurrieri0Silvia Corbellini1Giorgio Piccinelli2Alessandro Turra3Enrico Morello4Michele Malagola5Domenico Russo6Arnaldo Caruso7Maria Antonia De Francesco8Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyChair of Hematology, Unit of Blood Diseases and Stem Cells Transplantation, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyChair of Hematology, Unit of Blood Diseases and Stem Cells Transplantation, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyChair of Hematology, Unit of Blood Diseases and Stem Cells Transplantation, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyChair of Hematology, Unit of Blood Diseases and Stem Cells Transplantation, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, ItalyDepartment of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, Italy<i>Saprochaete capitata</i> is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in those affected by acute leukemia. An important risk factor that predisposes to this infection is the profound neutropenia present in such immunocompromised patients. <i>Saprochaete</i> spp. were found resistant to both echinocandins and fluconazole so the treatment is often difficult. Here, we report two cases of sepsis in two patients with acute leukemia. All of them had fatal events, due to the worsening of their clinical condition. An early diagnosis and appropriate management of these pathogens is important in consideration of the poor prognosis associated to these fungal invasive infections.https://www.mdpi.com/2076-393X/9/11/1289immunosuppressionfungal infectionneutropeniabone marrow transplantation |
| spellingShingle | Francesca Gurrieri Silvia Corbellini Giorgio Piccinelli Alessandro Turra Enrico Morello Michele Malagola Domenico Russo Arnaldo Caruso Maria Antonia De Francesco Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies Vaccines immunosuppression fungal infection neutropenia bone marrow transplantation |
| title | Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies |
| title_full | Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies |
| title_fullStr | Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies |
| title_full_unstemmed | Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies |
| title_short | Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies |
| title_sort | management of invasive infections due to a rare arthroconidial yeast i saprochaete capitata i in two patients with acute hematological malignancies |
| topic | immunosuppression fungal infection neutropenia bone marrow transplantation |
| url | https://www.mdpi.com/2076-393X/9/11/1289 |
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