Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells
Objective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense. We studied the effects of folic acid on the apoptosis of breast cancer cells (MDA-MB-231) and on the activity of the PTEN/AKT/P53 si...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2020-10-01
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| Series: | Pteridines |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pteridines-2020-0020 |
| _version_ | 1797987709611933696 |
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| author | Wang Hexian Fan Qiang Zhang Longlong Shi Danli Wang Haibo Wang Shoulian Bian Bangjian |
| author_facet | Wang Hexian Fan Qiang Zhang Longlong Shi Danli Wang Haibo Wang Shoulian Bian Bangjian |
| author_sort | Wang Hexian |
| collection | DOAJ |
| description | Objective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense. We studied the effects of folic acid on the apoptosis of breast cancer cells (MDA-MB-231) and on the activity of the PTEN/AKT/P53 signaling pathway in breast cancer cells. |
| first_indexed | 2024-04-11T07:51:51Z |
| format | Article |
| id | doaj.art-a475342038d04f4b99e655b47c64605a |
| institution | Directory Open Access Journal |
| issn | 0933-4807 2195-4720 |
| language | English |
| last_indexed | 2024-04-11T07:51:51Z |
| publishDate | 2020-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pteridines |
| spelling | doaj.art-a475342038d04f4b99e655b47c64605a2022-12-22T04:36:03ZengDe GruyterPteridines0933-48072195-47202020-10-0131115816410.1515/pteridines-2020-0020pteridines-2020-0020Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cellsWang Hexian0Fan Qiang1Zhang Longlong2Shi Danli3Wang Haibo4Wang Shoulian5Bian Bangjian6Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Shanghai 9th People’s Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaObjective Folate deficiency is closely related to the occurrence of human tumors and plays an important role in cell growth, differentiation, repair, and host defense. We studied the effects of folic acid on the apoptosis of breast cancer cells (MDA-MB-231) and on the activity of the PTEN/AKT/P53 signaling pathway in breast cancer cells.https://doi.org/10.1515/pteridines-2020-0020folic acidbreast cancer cellapoptosisptenakt/p53 signaling pathway |
| spellingShingle | Wang Hexian Fan Qiang Zhang Longlong Shi Danli Wang Haibo Wang Shoulian Bian Bangjian Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells Pteridines folic acid breast cancer cell apoptosis pten akt/p53 signaling pathway |
| title | Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells |
| title_full | Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells |
| title_fullStr | Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells |
| title_full_unstemmed | Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells |
| title_short | Folate-targeted PTEN/AKT/P53 signaling pathway promotes apoptosis in breast cancer cells |
| title_sort | folate targeted pten akt p53 signaling pathway promotes apoptosis in breast cancer cells |
| topic | folic acid breast cancer cell apoptosis pten akt/p53 signaling pathway |
| url | https://doi.org/10.1515/pteridines-2020-0020 |
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