Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma
Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation together with increased oxidative stress that lead to clinical symptoms of asthma. Obesity is a known risk factor of asthma as the obesity is correlated with systemic inflammation and airway restriction. C...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2019-06-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/556 |
| _version_ | 1797223941969805312 |
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| author | Sura Abbas Khdair Manal Khalid Abdulridha Mostafa Abdal Fatah |
| author_facet | Sura Abbas Khdair Manal Khalid Abdulridha Mostafa Abdal Fatah |
| author_sort | Sura Abbas Khdair |
| collection | DOAJ |
| description |
Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation together with increased oxidative stress that lead to clinical symptoms of asthma.
Obesity is a known risk factor of asthma as the obesity is correlated with systemic inflammation and airway restriction. Curcumin, a natural product derived from the rhizomes of Curcuma longa (Turmeric), has a wide range of beneficial properties including anti-inflammatory and weight reducing agent. This study was designed to evaluate the effect of curcumin as supplement therapy on the pulmonary function, total and differential white blood cell count and metabolic status of chronic bronchial asthmatic patients. It is a prospective randomized controlled interventional study carried out on 40 patients visiting Al-Yarmouk teaching hospital and conducted from October 2017 to April 2018. The patients were allocated into group1; include 17 asthmatic patients assigned to receive conventional therapy for asthma alone, and group 2; include 23 asthmatic patients assigned to receive conventional therapy for asthma plus 750 mg curcumin capsule twice daily for two months. Results revealed significant improvement in forced expiratory volume in one second (FEV1) and the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) in group 2 patients after two months(P<0.01). The total white blood cell count didn’t show any difference after treatment except decrease in neutrophil count after curcumin supplement (p< 0.05). The leptin level and body mass index present with no significant difference in both groups after two months (p >0.05).
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| first_indexed | 2024-04-24T13:45:14Z |
| format | Article |
| id | doaj.art-a475cc5f90e743438385398f6a17f76c |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:14Z |
| publishDate | 2019-06-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-a475cc5f90e743438385398f6a17f76c2024-04-04T06:57:55ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2019-06-0119210.32947/ajps.v19i2.556Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial AsthmaSura Abbas Khdair0Manal Khalid Abdulridha1Mostafa Abdal Fatah2Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Iraq.Department of Clinical Pharmacy, College of Pharmacy, Al-Mustansiriyah University, Iraq.Department of Internal Medicine, Al-Yarmouk Teaching Hospital, Iraq Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation together with increased oxidative stress that lead to clinical symptoms of asthma. Obesity is a known risk factor of asthma as the obesity is correlated with systemic inflammation and airway restriction. Curcumin, a natural product derived from the rhizomes of Curcuma longa (Turmeric), has a wide range of beneficial properties including anti-inflammatory and weight reducing agent. This study was designed to evaluate the effect of curcumin as supplement therapy on the pulmonary function, total and differential white blood cell count and metabolic status of chronic bronchial asthmatic patients. It is a prospective randomized controlled interventional study carried out on 40 patients visiting Al-Yarmouk teaching hospital and conducted from October 2017 to April 2018. The patients were allocated into group1; include 17 asthmatic patients assigned to receive conventional therapy for asthma alone, and group 2; include 23 asthmatic patients assigned to receive conventional therapy for asthma plus 750 mg curcumin capsule twice daily for two months. Results revealed significant improvement in forced expiratory volume in one second (FEV1) and the ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC) in group 2 patients after two months(P<0.01). The total white blood cell count didn’t show any difference after treatment except decrease in neutrophil count after curcumin supplement (p< 0.05). The leptin level and body mass index present with no significant difference in both groups after two months (p >0.05). https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/556chronic bronchial asthma, pulmonary function, leptin, curcumin supplement |
| spellingShingle | Sura Abbas Khdair Manal Khalid Abdulridha Mostafa Abdal Fatah Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma Al-Mustansiriyah Journal of Pharmaceutical Sciences chronic bronchial asthma, pulmonary function, leptin, curcumin supplement |
| title | Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma |
| title_full | Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma |
| title_fullStr | Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma |
| title_full_unstemmed | Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma |
| title_short | Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma |
| title_sort | effect of curcumin supplement on pulmonary functions total and differential white blood cell count serum level of leptin and body mass index in a sample of iraqi patients with chronic bronchial asthma |
| topic | chronic bronchial asthma, pulmonary function, leptin, curcumin supplement |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/556 |
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