The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia
Introduction. Adherence to proposed lifestyle changes and prescribed medication in patients with stable coronary artery disease (SCAD) is poor. Objective. We sought to investigate the influence of adjusting guideline proposed medications on relief of angina in a large group of patients with...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Medical Society
2016-01-01
|
| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2016/0370-81791612590I.pdf |
| _version_ | 1818453288869167104 |
|---|---|
| author | Ilić Ivan Stanković Ivan Janićijević Aleksandra Kušić Jovana Vidaković Radosav Otašević Petar Andrić Vesna Poznanović Snežana Petrović Ivana Burazor Ivana Ristić Arsen Ilić Stevan Benc Dragan Davidović Goran Stojković Gabrijela Putniković Biljana Nešković Aleksandar N. |
| author_facet | Ilić Ivan Stanković Ivan Janićijević Aleksandra Kušić Jovana Vidaković Radosav Otašević Petar Andrić Vesna Poznanović Snežana Petrović Ivana Burazor Ivana Ristić Arsen Ilić Stevan Benc Dragan Davidović Goran Stojković Gabrijela Putniković Biljana Nešković Aleksandar N. |
| author_sort | Ilić Ivan |
| collection | DOAJ |
| description | Introduction. Adherence to proposed lifestyle changes and prescribed
medication in patients with stable coronary artery disease (SCAD) is poor.
Objective. We sought to investigate the influence of adjusting guideline
proposed medications on relief of angina in a large group of patients with
SCAD in Serbia. Methods. The study included a total of 3,490 patients from 15
cardiology clinics with symptoms of stable angina and at least one of the
following criteria: abnormal electrocardiogram (ECG), history of myocardial
infarction (MI), positive stress test, significant coronary artery disease on
coronary angiogram or previous revascularization. All the patients underwent
comprehensive evaluation at initial visit and after two months. The relief of
angina was study end-point defined as any reduction in Canadian Cardiology
Society (CCS) class, number of angina attacks per week and/or number of
tablets of short-acting nitrates per week. Results. Most patients were
included based on abnormal ECG (48.4%). At Visit 1, the average number of
prescribed classes of medications to a single patient increased from 4.16 ±
1.29 to 4.63 ± 1.57 (p < 0.001). At the follow-up, the patients had
significantly lower blood pressure (141 ± 19 / 85 ± 11 vs. 130 ± 12 / 80 ± 8
mmHg; p < 0.001) and most of them reported CCS class I (63.3%). The average
weekly number of angina attacks was reduced from 2.82 ± 2.50 at Visit 1 to
1.72 0 ± 1.66 at Visit 2, as well as average weekly use of short-acting
nitrates to treat these attacks (2.69 ± 2.53 to 1.74 ± 1.47 tablets; p <
0.001 for all). Conclusion. Adjustment of prescribed medications to guideline
recommendations in a large Serbian patient population with prevalent risk
factors led to significant relief of angina. |
| first_indexed | 2024-12-14T21:36:37Z |
| format | Article |
| id | doaj.art-a47704a3b0fb4c53837cf4c274d10d0e |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-12-14T21:36:37Z |
| publishDate | 2016-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-a47704a3b0fb4c53837cf4c274d10d0e2022-12-21T22:46:34ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952016-01-0114411-1259059610.2298/SARH1612590I0370-81791612590IThe effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in SerbiaIlić Ivan0Stanković Ivan1Janićijević Aleksandra2Kušić Jovana3Vidaković Radosav4Otašević Petar5Andrić Vesna6Poznanović Snežana7Petrović Ivana8Burazor Ivana9Ristić Arsen10Ilić Stevan11Benc Dragan12Davidović Goran13Stojković Gabrijela14Putniković Biljana15Nešković Aleksandar N.16School of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Cardiology, BelgradeSchool of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Cardiology, BelgradeSchool of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Cardiology, BelgradeSchool of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Nephrology, BelgradeSchool of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Cardiology, BelgradeSchool of Medicine, Belgrade + Dedinje Cardiovascular Institute, Department of Cardiology, BelgradeInstitute for Health Care of Railway Workers, Department of Internal Medicine, BelgradePublic Health Center, Veliko GradišteSchool of Medicine, Belgrade + Public Health Center Vračar, BelgradeSchool of Medicine, Belgrade + Rehabilitation Clinic “Dr Miroslav Zotović”, BelgradeSchool of Medicine, Belgrade + Clinical Center of Serbia, Cardiology Clinic, BelgradeFaculty of Medicine, Niš + Niška Banja Institute, Niška BanjaFaculty of Medicine, Novi Sad + Institute for Cardiovascular Diseases, Clinic of Cardiology, Sremska KamenicaFaculty of Medical Sciences, Kragujevac + Clinical Center of Kragujevac, KragujevacGeneral Hospital, LeskovacSchool of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Cardiology, BelgradeSchool of Medicine, Belgrade + Clinical Hospital Center Zemun, Department of Cardiology, BelgradeIntroduction. Adherence to proposed lifestyle changes and prescribed medication in patients with stable coronary artery disease (SCAD) is poor. Objective. We sought to investigate the influence of adjusting guideline proposed medications on relief of angina in a large group of patients with SCAD in Serbia. Methods. The study included a total of 3,490 patients from 15 cardiology clinics with symptoms of stable angina and at least one of the following criteria: abnormal electrocardiogram (ECG), history of myocardial infarction (MI), positive stress test, significant coronary artery disease on coronary angiogram or previous revascularization. All the patients underwent comprehensive evaluation at initial visit and after two months. The relief of angina was study end-point defined as any reduction in Canadian Cardiology Society (CCS) class, number of angina attacks per week and/or number of tablets of short-acting nitrates per week. Results. Most patients were included based on abnormal ECG (48.4%). At Visit 1, the average number of prescribed classes of medications to a single patient increased from 4.16 ± 1.29 to 4.63 ± 1.57 (p < 0.001). At the follow-up, the patients had significantly lower blood pressure (141 ± 19 / 85 ± 11 vs. 130 ± 12 / 80 ± 8 mmHg; p < 0.001) and most of them reported CCS class I (63.3%). The average weekly number of angina attacks was reduced from 2.82 ± 2.50 at Visit 1 to 1.72 0 ± 1.66 at Visit 2, as well as average weekly use of short-acting nitrates to treat these attacks (2.69 ± 2.53 to 1.74 ± 1.47 tablets; p < 0.001 for all). Conclusion. Adjustment of prescribed medications to guideline recommendations in a large Serbian patient population with prevalent risk factors led to significant relief of angina.http://www.doiserbia.nb.rs/img/doi/0370-8179/2016/0370-81791612590I.pdfstable coronary artery diseaseguidelinesmedical therapytrimetazidine |
| spellingShingle | Ilić Ivan Stanković Ivan Janićijević Aleksandra Kušić Jovana Vidaković Radosav Otašević Petar Andrić Vesna Poznanović Snežana Petrović Ivana Burazor Ivana Ristić Arsen Ilić Stevan Benc Dragan Davidović Goran Stojković Gabrijela Putniković Biljana Nešković Aleksandar N. The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia Srpski Arhiv za Celokupno Lekarstvo stable coronary artery disease guidelines medical therapy trimetazidine |
| title | The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia |
| title_full | The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia |
| title_fullStr | The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia |
| title_full_unstemmed | The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia |
| title_short | The effects of implementation of guideline-directed medical therapy on relief of angina in patients with stable coronary artery disease in Serbia |
| title_sort | effects of implementation of guideline directed medical therapy on relief of angina in patients with stable coronary artery disease in serbia |
| topic | stable coronary artery disease guidelines medical therapy trimetazidine |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2016/0370-81791612590I.pdf |
| work_keys_str_mv | AT ilicivan theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT stankovicivan theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT janicijevicaleksandra theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT kusicjovana theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT vidakovicradosav theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT otasevicpetar theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT andricvesna theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT poznanovicsnezana theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT petrovicivana theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT burazorivana theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT risticarsen theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT ilicstevan theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT bencdragan theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT davidovicgoran theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT stojkovicgabrijela theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT putnikovicbiljana theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT neskovicaleksandarn theeffectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT ilicivan effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT stankovicivan effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT janicijevicaleksandra effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT kusicjovana effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT vidakovicradosav effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT otasevicpetar effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT andricvesna effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT poznanovicsnezana effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT petrovicivana effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT burazorivana effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT risticarsen effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT ilicstevan effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT bencdragan effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT davidovicgoran effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT stojkovicgabrijela effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT putnikovicbiljana effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia AT neskovicaleksandarn effectsofimplementationofguidelinedirectedmedicaltherapyonreliefofanginainpatientswithstablecoronaryarterydiseaseinserbia |