New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization
Plicosepalus curviflorus is distributed in Africa, Yemen and Saudi Arabia and applied to treat cancer, tonsillitis, otitis media and for curing diabetes. The objective of this study is to isolate chemical constituents from this medicinally important plant and it yielded one undescribed gallocatechin...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S101836472030402X |
| _version_ | 1818734118723125248 |
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| author | Areej Mohammad Al-Taweel Shagufta Perveen Saleh Ibrahim Alqasoumi Raha Orfali Hanan Y. Aati Shahnaz Ebtesam Nasser Alsultan Bandar Alghanem Hayat Shaibah |
| author_facet | Areej Mohammad Al-Taweel Shagufta Perveen Saleh Ibrahim Alqasoumi Raha Orfali Hanan Y. Aati Shahnaz Ebtesam Nasser Alsultan Bandar Alghanem Hayat Shaibah |
| author_sort | Areej Mohammad Al-Taweel |
| collection | DOAJ |
| description | Plicosepalus curviflorus is distributed in Africa, Yemen and Saudi Arabia and applied to treat cancer, tonsillitis, otitis media and for curing diabetes. The objective of this study is to isolate chemical constituents from this medicinally important plant and it yielded one undescribed gallocatechin derivative 1 along with nine known compounds 2–10. In this study, the metabolite profiling of n-butanol fraction of P. curviflorus was also measured by using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOf-MS). Our research provided the facts for the theory that this plant is a good source of flavane and flavonoids and can be used as medicine. This application allowed to unambiguously identify eight compounds 11–18 from n-butanol soluble fraction of P. curviflorus. We describe here complete characterization of one new compound isolated from the n-butanol soluble fraction of P. curviflorus by NMR and ESI-MS. To the best of our good grasp, compounds 12–15, represents the example of substituted catechin derivatives identified by LC-QTOf-MS method. |
| first_indexed | 2024-12-18T00:00:17Z |
| format | Article |
| id | doaj.art-a4777ee9f12d4af98ea067a828a9af1c |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-12-18T00:00:17Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-a4777ee9f12d4af98ea067a828a9af1c2022-12-21T21:27:58ZengElsevierJournal of King Saud University: Science1018-36472021-03-01332101289New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterizationAreej Mohammad Al-Taweel0Shagufta Perveen1Saleh Ibrahim Alqasoumi2Raha Orfali3Hanan Y. Aati4 Shahnaz5Ebtesam Nasser Alsultan6Bandar Alghanem7Hayat Shaibah8Department of Pharmacogonosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacogonosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Corresponding author.Department of Pharmacogonosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacogonosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmacogonosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaLahore College for Women University, Lahore, PakistanDepartment of Pharmacogonosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City (KAMC), NGHA, Riyadh 11426, Saudi ArabiaMedical Research Core Facility and Platforms, King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City (KAMC), NGHA, Riyadh 11426, Saudi ArabiaPlicosepalus curviflorus is distributed in Africa, Yemen and Saudi Arabia and applied to treat cancer, tonsillitis, otitis media and for curing diabetes. The objective of this study is to isolate chemical constituents from this medicinally important plant and it yielded one undescribed gallocatechin derivative 1 along with nine known compounds 2–10. In this study, the metabolite profiling of n-butanol fraction of P. curviflorus was also measured by using liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOf-MS). Our research provided the facts for the theory that this plant is a good source of flavane and flavonoids and can be used as medicine. This application allowed to unambiguously identify eight compounds 11–18 from n-butanol soluble fraction of P. curviflorus. We describe here complete characterization of one new compound isolated from the n-butanol soluble fraction of P. curviflorus by NMR and ESI-MS. To the best of our good grasp, compounds 12–15, represents the example of substituted catechin derivatives identified by LC-QTOf-MS method.http://www.sciencedirect.com/science/article/pii/S101836472030402XPlicosepalus curviflorusFlavane gallatesCatechin derivatives |
| spellingShingle | Areej Mohammad Al-Taweel Shagufta Perveen Saleh Ibrahim Alqasoumi Raha Orfali Hanan Y. Aati Shahnaz Ebtesam Nasser Alsultan Bandar Alghanem Hayat Shaibah New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization Journal of King Saud University: Science Plicosepalus curviflorus Flavane gallates Catechin derivatives |
| title | New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization |
| title_full | New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization |
| title_fullStr | New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization |
| title_full_unstemmed | New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization |
| title_short | New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC-MS and NMR based molecular characterization |
| title_sort | new flavane gallates from the aerial part of an african arabian medicinal plant plicosepalus curviflorus by lc ms and nmr based molecular characterization |
| topic | Plicosepalus curviflorus Flavane gallates Catechin derivatives |
| url | http://www.sciencedirect.com/science/article/pii/S101836472030402X |
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