AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics
Abstract The aggregation‐induced emission luminogens (AIEgens) with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes. In this review, we first presented numeral classic types of delivery systems based on light‐up AIEgens for real‐time monitor...
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Aggregate |
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| Online Access: | https://doi.org/10.1002/agt2.282 |
| _version_ | 1797976245053423616 |
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| author | Jie Sun Xuewen He |
| author_facet | Jie Sun Xuewen He |
| author_sort | Jie Sun |
| collection | DOAJ |
| description | Abstract The aggregation‐induced emission luminogens (AIEgens) with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes. In this review, we first presented numeral classic types of delivery systems based on light‐up AIEgens for real‐time monitoring of the delivery processes and evaluation of therapeutic outcomes of delivered drugs or genes. Next, general strategies were discussed for the delicately structural design of AIEgens that can self‐assemble into bright therapeutic carriers through covalent or noncovalent interactions. Furthermore, given the unprecedented enhancements in therapeutic effects through the use of multimodes of therapy, AIEgens that were endowed with multi‐properties and functionalities were investigated in the constructions of delivery systems for multimodality therapy. Especially, the combinational uses of AIE photosensitizers with chemo drug and small interference RNA (siRNA) were given as examples of augmenting the therapeutic performance in drug‐resistant treatment and moderate immunotherapy by showing synergistic effects. |
| first_indexed | 2024-04-11T04:48:01Z |
| format | Article |
| id | doaj.art-a477d98aa8114ebea432f0eca929dc34 |
| institution | Directory Open Access Journal |
| issn | 2692-4560 |
| language | English |
| last_indexed | 2024-04-11T04:48:01Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Aggregate |
| spelling | doaj.art-a477d98aa8114ebea432f0eca929dc342022-12-27T06:37:38ZengWileyAggregate2692-45602022-12-0136n/an/a10.1002/agt2.282AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeuticsJie Sun0Xuewen He1The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou ChinaThe Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou ChinaAbstract The aggregation‐induced emission luminogens (AIEgens) with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes. In this review, we first presented numeral classic types of delivery systems based on light‐up AIEgens for real‐time monitoring of the delivery processes and evaluation of therapeutic outcomes of delivered drugs or genes. Next, general strategies were discussed for the delicately structural design of AIEgens that can self‐assemble into bright therapeutic carriers through covalent or noncovalent interactions. Furthermore, given the unprecedented enhancements in therapeutic effects through the use of multimodes of therapy, AIEgens that were endowed with multi‐properties and functionalities were investigated in the constructions of delivery systems for multimodality therapy. Especially, the combinational uses of AIE photosensitizers with chemo drug and small interference RNA (siRNA) were given as examples of augmenting the therapeutic performance in drug‐resistant treatment and moderate immunotherapy by showing synergistic effects.https://doi.org/10.1002/agt2.282aggregation‐induced emissioncombinational therapydelivery systemsfluorescence imagingself‐assembly |
| spellingShingle | Jie Sun Xuewen He AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics Aggregate aggregation‐induced emission combinational therapy delivery systems fluorescence imaging self‐assembly |
| title | AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics |
| title_full | AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics |
| title_fullStr | AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics |
| title_full_unstemmed | AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics |
| title_short | AIE‐based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics |
| title_sort | aie based drug gene delivery system evolution from fluorescence monitoring alone to augmented therapeutics |
| topic | aggregation‐induced emission combinational therapy delivery systems fluorescence imaging self‐assembly |
| url | https://doi.org/10.1002/agt2.282 |
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