Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian
Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patie...
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| Format: | Article |
| Language: | English |
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BMC
2022-04-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02588-w |
| _version_ | 1818266848075972608 |
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| author | Anqi Lin Ningning Zhou Weiliang Zhu Jiexia Zhang Ting Wei Linlang Guo Peng Luo Jian Zhang |
| author_facet | Anqi Lin Ningning Zhou Weiliang Zhu Jiexia Zhang Ting Wei Linlang Guo Peng Luo Jian Zhang |
| author_sort | Anqi Lin |
| collection | DOAJ |
| description | Abstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival. |
| first_indexed | 2024-12-12T20:13:13Z |
| format | Article |
| id | doaj.art-a479861fe7c64f5daf01a52c0b10ae36 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-12T20:13:13Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-a479861fe7c64f5daf01a52c0b10ae362022-12-22T00:13:28ZengBMCCancer Cell International1475-28672022-04-0122111610.1186/s12935-022-02588-wGenomic and immunological profiles of small-cell lung cancer between East Asians and CaucasianAnqi Lin0Ningning Zhou1Weiliang Zhu2Jiexia Zhang3Ting Wei4Linlang Guo5Peng Luo6Jian Zhang7Department of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer CenterDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory DiseaseDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Pathology, Zhujiang Hospital, Southern Medical UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityDepartment of Oncology, Zhujiang Hospital, Southern Medical UniversityAbstract The characterization of immunological and genomic differences in small-cell lung cancer (SCLC) between East Asian (EA) and Caucasian patients can reveal important clinical therapies for EA patients with SCLC. By sequencing and analyzing a molecular and immunological dataset of 98-SCLC patients of EA ancestry, immunogenicity, including DNA damage repair alterations and tumor mutation burden (TMB), was found to be significantly higher in the EA cohort than in the Caucasian cohort. The epithelial-mesenchymal transition (EMT) was the signaling signature with the predominant frequency of mutations across all patients in the EA cohort. Analysis of tumor-infiltrated immune cells revealed that resting lymphocytes were significantly enriched in the EA cohort. Compound-targeting analysis showed that topoisomerase inhibitors might be capable of targeting TP53 and RB1 comutations in EA SCLC patients. EA SCLC patients who harbored COL6A6 mutations had poor survival, while Caucasian SCLC patients with OTOF, ANKRD30B, and TECPR2 mutations were identified to have a shorter survival.https://doi.org/10.1186/s12935-022-02588-wSCLCEast AsianCaucasianGenomicImmune-infiltrating |
| spellingShingle | Anqi Lin Ningning Zhou Weiliang Zhu Jiexia Zhang Ting Wei Linlang Guo Peng Luo Jian Zhang Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian Cancer Cell International SCLC East Asian Caucasian Genomic Immune-infiltrating |
| title | Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian |
| title_full | Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian |
| title_fullStr | Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian |
| title_full_unstemmed | Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian |
| title_short | Genomic and immunological profiles of small-cell lung cancer between East Asians and Caucasian |
| title_sort | genomic and immunological profiles of small cell lung cancer between east asians and caucasian |
| topic | SCLC East Asian Caucasian Genomic Immune-infiltrating |
| url | https://doi.org/10.1186/s12935-022-02588-w |
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