Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen
Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies deve...
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| Format: | Article |
| Language: | deu |
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Swiss Chemical Society
2017-04-01
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| Series: | CHIMIA |
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| Online Access: | https://www.chimia.ch/chimia/article/view/1584 |
| _version_ | 1818295803782889472 |
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| author | Vincent Lebrun |
| author_facet | Vincent Lebrun |
| author_sort | Vincent Lebrun |
| collection | DOAJ |
| description |
Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies
developed to date, and at presenting the development of an artificial zymogen, which is upregulated by a natural protease. In our view, this constitutes a first step towards the cellular control of the activity of an artificial metalloenzyme.
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| first_indexed | 2024-12-13T03:53:27Z |
| format | Article |
| id | doaj.art-a47b993dcbdd4036896236892ed6df53 |
| institution | Directory Open Access Journal |
| issn | 0009-4293 2673-2424 |
| language | deu |
| last_indexed | 2024-12-13T03:53:27Z |
| publishDate | 2017-04-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj.art-a47b993dcbdd4036896236892ed6df532022-12-22T00:00:40ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242017-04-0171410.2533/chimia.2017.199Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial ZymogenVincent Lebrun0Department of Chemistry University of Basel CH-4056 Basel, Switzerland. vincent.lebrun@unibas.ch Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies developed to date, and at presenting the development of an artificial zymogen, which is upregulated by a natural protease. In our view, this constitutes a first step towards the cellular control of the activity of an artificial metalloenzyme. https://www.chimia.ch/chimia/article/view/1584Artificial metalloenzymeCatalysisCross regulationTransfer hydrogenationZymogen |
| spellingShingle | Vincent Lebrun Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen CHIMIA Artificial metalloenzyme Catalysis Cross regulation Transfer hydrogenation Zymogen |
| title | Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen |
| title_full | Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen |
| title_fullStr | Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen |
| title_full_unstemmed | Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen |
| title_short | Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen |
| title_sort | towards cellular activation of an artificial metalloenzyme development of an artificial zymogen |
| topic | Artificial metalloenzyme Catalysis Cross regulation Transfer hydrogenation Zymogen |
| url | https://www.chimia.ch/chimia/article/view/1584 |
| work_keys_str_mv | AT vincentlebrun towardscellularactivationofanartificialmetalloenzymedevelopmentofanartificialzymogen |