<i>Salmonella</i> Bloodstream Infections
<i>Salmonella</i> is a major foodborne pathogen of both animals and humans. This bacterium is responsible for considerable morbidity and mortality world-wide. Different serovars of this genus cause diseases ranging from self-limiting gastroenteritis to a potentially fatal systemic diseas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/8/11/487 |
| _version_ | 1797457632542326784 |
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| author | Micah J. Worley |
| author_facet | Micah J. Worley |
| author_sort | Micah J. Worley |
| collection | DOAJ |
| description | <i>Salmonella</i> is a major foodborne pathogen of both animals and humans. This bacterium is responsible for considerable morbidity and mortality world-wide. Different serovars of this genus cause diseases ranging from self-limiting gastroenteritis to a potentially fatal systemic disease known as enteric fever. Gastrointestinal infections with <i>Salmonella</i> are usually self-limiting and rarely require medical intervention. Bloodstream infections, on the other hand, are often fatal even with hospitalization. This review describes the routes and underlying mechanisms of the extraintestinal dissemination of <i>Salmonella</i> and the chronic infections that sometimes result. It includes information on the pathogenicity islands and individual virulence factors involved in systemic dissemination as well as a discussion of the host factors that mediate susceptibility. Also, the major outbreaks of invasive <i>Salmonella</i> disease in the tropics are described. |
| first_indexed | 2024-03-09T16:24:49Z |
| format | Article |
| id | doaj.art-a47de9d6906a45219242a0bae043bf6b |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-09T16:24:49Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-a47de9d6906a45219242a0bae043bf6b2023-11-24T15:09:40ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-10-0181148710.3390/tropicalmed8110487<i>Salmonella</i> Bloodstream InfectionsMicah J. Worley0Department of Biology, University of Louisville, Louisville, KY 40292, USA<i>Salmonella</i> is a major foodborne pathogen of both animals and humans. This bacterium is responsible for considerable morbidity and mortality world-wide. Different serovars of this genus cause diseases ranging from self-limiting gastroenteritis to a potentially fatal systemic disease known as enteric fever. Gastrointestinal infections with <i>Salmonella</i> are usually self-limiting and rarely require medical intervention. Bloodstream infections, on the other hand, are often fatal even with hospitalization. This review describes the routes and underlying mechanisms of the extraintestinal dissemination of <i>Salmonella</i> and the chronic infections that sometimes result. It includes information on the pathogenicity islands and individual virulence factors involved in systemic dissemination as well as a discussion of the host factors that mediate susceptibility. Also, the major outbreaks of invasive <i>Salmonella</i> disease in the tropics are described.https://www.mdpi.com/2414-6366/8/11/487<i>Salmonella</i>bacteremiasepsisbloodstream infectionsserovarspathogenicity islands |
| spellingShingle | Micah J. Worley <i>Salmonella</i> Bloodstream Infections Tropical Medicine and Infectious Disease <i>Salmonella</i> bacteremia sepsis bloodstream infections serovars pathogenicity islands |
| title | <i>Salmonella</i> Bloodstream Infections |
| title_full | <i>Salmonella</i> Bloodstream Infections |
| title_fullStr | <i>Salmonella</i> Bloodstream Infections |
| title_full_unstemmed | <i>Salmonella</i> Bloodstream Infections |
| title_short | <i>Salmonella</i> Bloodstream Infections |
| title_sort | i salmonella i bloodstream infections |
| topic | <i>Salmonella</i> bacteremia sepsis bloodstream infections serovars pathogenicity islands |
| url | https://www.mdpi.com/2414-6366/8/11/487 |
| work_keys_str_mv | AT micahjworley isalmonellaibloodstreaminfections |