Mechanisms of non-coding RNA-modulated alternative splicing in cancer
Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | RNA Biology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15476286.2022.2062846 |
| _version_ | 1797403984598663168 |
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| author | Xiaolin Wang Jinghan Hua Jingxin Li Jiahui Zhang Emmanuel Enoch Dzakah Guozhen Cao Wenchu Lin |
| author_facet | Xiaolin Wang Jinghan Hua Jingxin Li Jiahui Zhang Emmanuel Enoch Dzakah Guozhen Cao Wenchu Lin |
| author_sort | Xiaolin Wang |
| collection | DOAJ |
| description | Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis. |
| first_indexed | 2024-03-09T02:46:29Z |
| format | Article |
| id | doaj.art-a47f42f47bda4e76b17571bc7171ee83 |
| institution | Directory Open Access Journal |
| issn | 1547-6286 1555-8584 |
| language | English |
| last_indexed | 2024-03-09T02:46:29Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj.art-a47f42f47bda4e76b17571bc7171ee832023-12-05T16:09:51ZengTaylor & Francis GroupRNA Biology1547-62861555-85842022-12-0119154154710.1080/15476286.2022.20628462062846Mechanisms of non-coding RNA-modulated alternative splicing in cancerXiaolin Wang0Jinghan Hua1Jingxin Li2Jiahui Zhang3Emmanuel Enoch Dzakah4Guozhen Cao5Wenchu Lin6Hefei Institutes of Physical Science (Hips), Chinese Academy of SciencesHefei Institutes of Physical Science (Hips), Chinese Academy of SciencesUniversity of Science and Technology of ChinaHefei Institutes of Physical Science (Hips), Chinese Academy of SciencesSchool of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape CoastHefei Institutes of Physical Science (Hips), Chinese Academy of SciencesHefei Institutes of Physical Science (Hips), Chinese Academy of SciencesAlternative splicing (AS) is a common and pivotal process for eukaryotic gene expression regulation, which enables a precursor RNA to produce multiple transcript variants with diverse cellular functions. Aberrant AS represents a hallmark of cancer, engaged in all stages of tumorigenesis from initiation to metastasis. Accumulating pieces of evidence have revealed the involvement of non-coding RNAs (ncRNAs) in regulating AS in human cancers. In this review, we overview the underlying mechanisms of non-coding RNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) modulated AS at diverse levels in human cancers, and summarize their regulatory functions in tumorigenesis.http://dx.doi.org/10.1080/15476286.2022.2062846alternative splicingsplicing factorcancer progressionmirnalncrnacircrna |
| spellingShingle | Xiaolin Wang Jinghan Hua Jingxin Li Jiahui Zhang Emmanuel Enoch Dzakah Guozhen Cao Wenchu Lin Mechanisms of non-coding RNA-modulated alternative splicing in cancer RNA Biology alternative splicing splicing factor cancer progression mirna lncrna circrna |
| title | Mechanisms of non-coding RNA-modulated alternative splicing in cancer |
| title_full | Mechanisms of non-coding RNA-modulated alternative splicing in cancer |
| title_fullStr | Mechanisms of non-coding RNA-modulated alternative splicing in cancer |
| title_full_unstemmed | Mechanisms of non-coding RNA-modulated alternative splicing in cancer |
| title_short | Mechanisms of non-coding RNA-modulated alternative splicing in cancer |
| title_sort | mechanisms of non coding rna modulated alternative splicing in cancer |
| topic | alternative splicing splicing factor cancer progression mirna lncrna circrna |
| url | http://dx.doi.org/10.1080/15476286.2022.2062846 |
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