Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle
Abstract Background The habitual excessive intake of sugar (i.e., sucrose and high-fructose corn syrup), which has been implicated in the onset of diabetes mellitus, induces excessive production of glyceraldehyde, a metabolite produced during glucose and fructose metabolism, in hepatocytes, neuronal...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-020-00614-3 |
| _version_ | 1828977028960878592 |
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| author | Masayoshi Takeuchi |
| author_facet | Masayoshi Takeuchi |
| author_sort | Masayoshi Takeuchi |
| collection | DOAJ |
| description | Abstract Background The habitual excessive intake of sugar (i.e., sucrose and high-fructose corn syrup), which has been implicated in the onset of diabetes mellitus, induces excessive production of glyceraldehyde, a metabolite produced during glucose and fructose metabolism, in hepatocytes, neuronal cells, and cardiomyocytes. Main text Toxic advanced glycation end-products (toxic AGEs, TAGE) are formed from reactions between glyceraldehyde and intracellular proteins, and their accumulation contributes to various cellular disorders. TAGE leakage from cells affects the surrounding cells and increases serum TAGE levels, promoting the onset and/or development of lifestyle-related diseases (LSRD). Therefore, serum TAGE levels have potential as a novel biomarker for predicting the onset and/or progression of LSRD, and minimizing the effects of TAGE might help to prevent the onset and/or progression of LSRD. Serum TAGE levels are closely related to LSRD associated with the excessive ingestion of sugar and/or dietary AGEs. Conclusions The TAGE theory is also expected to open new perspectives for research into numerous other diseases. |
| first_indexed | 2024-12-14T14:50:34Z |
| format | Article |
| id | doaj.art-a480b4b0a9814671b57c71126ca48fae |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-14T14:50:34Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-a480b4b0a9814671b57c71126ca48fae2022-12-21T22:57:09ZengBMCDiabetology & Metabolic Syndrome1758-59962020-11-0112111210.1186/s13098-020-00614-3Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyleMasayoshi Takeuchi0Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical UniversityAbstract Background The habitual excessive intake of sugar (i.e., sucrose and high-fructose corn syrup), which has been implicated in the onset of diabetes mellitus, induces excessive production of glyceraldehyde, a metabolite produced during glucose and fructose metabolism, in hepatocytes, neuronal cells, and cardiomyocytes. Main text Toxic advanced glycation end-products (toxic AGEs, TAGE) are formed from reactions between glyceraldehyde and intracellular proteins, and their accumulation contributes to various cellular disorders. TAGE leakage from cells affects the surrounding cells and increases serum TAGE levels, promoting the onset and/or development of lifestyle-related diseases (LSRD). Therefore, serum TAGE levels have potential as a novel biomarker for predicting the onset and/or progression of LSRD, and minimizing the effects of TAGE might help to prevent the onset and/or progression of LSRD. Serum TAGE levels are closely related to LSRD associated with the excessive ingestion of sugar and/or dietary AGEs. Conclusions The TAGE theory is also expected to open new perspectives for research into numerous other diseases.https://doi.org/10.1186/s13098-020-00614-3Advanced glycation end-products (AGEs)GlyceraldehydeToxic AGEs (TAGE)SucroseHigh-fructose corn syrup (HFCS)Dietary AGEs |
| spellingShingle | Masayoshi Takeuchi Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle Diabetology & Metabolic Syndrome Advanced glycation end-products (AGEs) Glyceraldehyde Toxic AGEs (TAGE) Sucrose High-fructose corn syrup (HFCS) Dietary AGEs |
| title | Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle |
| title_full | Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle |
| title_fullStr | Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle |
| title_full_unstemmed | Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle |
| title_short | Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle |
| title_sort | toxic ages tage theory a new concept for preventing the development of diseases related to lifestyle |
| topic | Advanced glycation end-products (AGEs) Glyceraldehyde Toxic AGEs (TAGE) Sucrose High-fructose corn syrup (HFCS) Dietary AGEs |
| url | https://doi.org/10.1186/s13098-020-00614-3 |
| work_keys_str_mv | AT masayoshitakeuchi toxicagestagetheoryanewconceptforpreventingthedevelopmentofdiseasesrelatedtolifestyle |