Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome
Background: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis. Meth...
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MDPI AG
2020-05-01
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| Series: | Journal of Clinical Medicine |
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| author | Miho Nishitani-Yokoyama Katsumi Miyauchi Kazunori Shimada Takayuki Yokoyama Shohei Ouchi Tatsuro Aikawa Mitsuhiro Kunimoto Miki Yamada Akio Honzawa Shinya Okazaki Hiroaki Tsujita Shinji Koba Hiroyuki Daida |
| author_facet | Miho Nishitani-Yokoyama Katsumi Miyauchi Kazunori Shimada Takayuki Yokoyama Shohei Ouchi Tatsuro Aikawa Mitsuhiro Kunimoto Miki Yamada Akio Honzawa Shinya Okazaki Hiroaki Tsujita Shinji Koba Hiroyuki Daida |
| author_sort | Miho Nishitani-Yokoyama |
| collection | DOAJ |
| description | Background: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis. Methods: We retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA. Results: The baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level. Conclusions: Combined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS. |
| first_indexed | 2024-03-10T19:39:57Z |
| format | Article |
| id | doaj.art-a480d453c7754d799c3c8bcdacc490fa |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:39:57Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a480d453c7754d799c3c8bcdacc490fa2023-11-20T01:23:05ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0195157810.3390/jcm9051578Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary SyndromeMiho Nishitani-Yokoyama0Katsumi Miyauchi1Kazunori Shimada2Takayuki Yokoyama3Shohei Ouchi4Tatsuro Aikawa5Mitsuhiro Kunimoto6Miki Yamada7Akio Honzawa8Shinya Okazaki9Hiroaki Tsujita10Shinji Koba11Hiroyuki Daida12Department of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanCardiovascular Rehabilitation and Fitness, Juntendo University Hospital, Tokyo 113-8431, JapanCardiovascular Rehabilitation and Fitness, Juntendo University Hospital, Tokyo 113-8431, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanDivision of Cardiology, Department of Medicine, School of Medicine, Showa University, Tokyo 142-8666, JapanDivision of Cardiology, Department of Medicine, School of Medicine, Showa University, Tokyo 142-8666, JapanDepartment of Cardiovascular Medicine, Graduate School of Medicine, Juntendo University, Tokyo 113-8421, JapanBackground: We investigated the combined effects of physical activity (PA) and aggressive low-density lipoprotein cholesterol (LDL-C) reduction on the changes in coronary plaque volume (PV) in patients with acute coronary syndrome (ACS) using volumetric intravascular ultrasound (IVUS) analysis. Methods: We retrospectively analyzed data from two different prospective clinical trials that involved 101 ACS patients who underwent percutaneous coronary intervention (PCI) and assessed the non-culprit sites of PCI lesions using IVUS at baseline and at the follow-up. After PCI, all the patients participated in early phase II comprehensive cardiac rehabilitation. Patients were divided into four groups based on whether the average daily step count, measured using a pedometer, was 7000 steps of more and whether the follow-up LDL-C level was <70 mg/dL. At the time of follow-up, we examined the correlation of changes in the PV with LDL-C and PA. Results: The baseline characteristics of the four study groups were comparable. At the follow-up, plaque regression in both the achievement group (PA and LDL-C reduction) was higher than that in the other three groups. In addition, plaque reduction independently correlated with increased PA and reduction in LDL-C level. Conclusions: Combined therapy of intensive PA and achievement of LDL-C target retarded coronary PV in patients with ACS.https://www.mdpi.com/2077-0383/9/5/1578acute coronary syndromecardiac rehabilitationcoronary plaque regressionphysical activityachievement of LDL-C targetintegrated backscatter intravascular ultrasound |
| spellingShingle | Miho Nishitani-Yokoyama Katsumi Miyauchi Kazunori Shimada Takayuki Yokoyama Shohei Ouchi Tatsuro Aikawa Mitsuhiro Kunimoto Miki Yamada Akio Honzawa Shinya Okazaki Hiroaki Tsujita Shinji Koba Hiroyuki Daida Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome Journal of Clinical Medicine acute coronary syndrome cardiac rehabilitation coronary plaque regression physical activity achievement of LDL-C target integrated backscatter intravascular ultrasound |
| title | Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome |
| title_full | Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome |
| title_fullStr | Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome |
| title_short | Preliminary Pilot Study of Combined Effects of Physical Activity and Achievement of LDL-Cholesterol Target on Coronary Plaque Volume Changes in Patients with Acute Coronary Syndrome |
| title_sort | preliminary pilot study of combined effects of physical activity and achievement of ldl cholesterol target on coronary plaque volume changes in patients with acute coronary syndrome |
| topic | acute coronary syndrome cardiac rehabilitation coronary plaque regression physical activity achievement of LDL-C target integrated backscatter intravascular ultrasound |
| url | https://www.mdpi.com/2077-0383/9/5/1578 |
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