| Summary: | The field of technology assessment in telemedicine is garnering increasing attention due to the widespread adoption of this discipline and its complex and heterogeneous system characteristics, making its application complex. As part of a national telemedicine project, the National Center for Innovative Technologies in Public Health at the Italian National Institute of Health played the role of promoting and utilizing technology assessment tools within partnership projects. This study aims to outline the design, development, and application of assessment methodologies within the telemedicine project proposed by the ISS team, utilizing a specific framework developed within the project. The sub-objectives include evaluating the proposed methodology’s effectiveness and feasibility, gathering feedback for improvement, and assessing its impact on various project components. The study emphasizes the multifaceted nature of action domains and underscores the crucial role of technology assessments in telemedicine, highlighting its impact across diverse realms through iterative interaction cycles with project partners. Both the impact and the acceptance of the methodology have been assessed by means of specific computer-aided web interviewing (CAWI) tools. The proposed methodology received significant acceptance, providing valuable insights for refining future frameworks. The impact assessment revealed a consistent quality improvement trend in the project’s products, evident in methodological consolidations. The overall message encourages similar initiatives in this domain, shedding light on the intricacies of technology assessment implementation. In conclusion, the study serves as a comprehensive outcome of the national telemedicine project, witnessing the success and adaptability of the technology assessment methodology and advocating for further exploration and implementation in analogous contexts.
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