Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma
Glioblastoma (GBM) is characterized by local and systemic immunosuppression, showing limited responses to immunotherapies. Here the authors describe the design of a nanoplatform composed of the lymphopenia alleviating agent cannabidiol and the lymphocyte recruiting cytokine LIGHT, promoting anti-tum...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-35957-8 |
| _version_ | 1811175827883163648 |
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| author | Songlei Zhou Yukun Huang Yu Chen Yipu Liu Laozhi Xie Yang You Shiqiang Tong Jianpei Xu Gan Jiang Qingxiang Song Ni Mei Fenfen Ma Xiaoling Gao Hongzhuan Chen Jun Chen |
| author_facet | Songlei Zhou Yukun Huang Yu Chen Yipu Liu Laozhi Xie Yang You Shiqiang Tong Jianpei Xu Gan Jiang Qingxiang Song Ni Mei Fenfen Ma Xiaoling Gao Hongzhuan Chen Jun Chen |
| author_sort | Songlei Zhou |
| collection | DOAJ |
| description | Glioblastoma (GBM) is characterized by local and systemic immunosuppression, showing limited responses to immunotherapies. Here the authors describe the design of a nanoplatform composed of the lymphopenia alleviating agent cannabidiol and the lymphocyte recruiting cytokine LIGHT, promoting anti-tumor immune responses in GBM preclinical models. |
| first_indexed | 2024-04-10T19:42:14Z |
| format | Article |
| id | doaj.art-a48196460e1543ec91af235e4cfdaf60 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T19:42:14Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a48196460e1543ec91af235e4cfdaf602023-01-29T12:16:25ZengNature PortfolioNature Communications2041-17232023-01-0114112010.1038/s41467-023-35957-8Reprogramming systemic and local immune function to empower immunotherapy against glioblastomaSonglei Zhou0Yukun Huang1Yu Chen2Yipu Liu3Laozhi Xie4Yang You5Shiqiang Tong6Jianpei Xu7Gan Jiang8Qingxiang Song9Ni Mei10Fenfen Ma11Xiaoling Gao12Hongzhuan Chen13Jun Chen14Department of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of MedicineDepartment of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of MedicineShanghai Center for Drug Evaluation and InspectionDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityDepartment of Pharmacology and Chemical Biology, State Key Laboratory of Oncogenes and Related Genes, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of MedicineInstitute of Interdisciplinary Integrative Medicine Research, Shuguang Hospital, Shanghai University of Traditional Chinese MedicineDepartment of Pharmaceutics, School of Pharmacy & Shanghai Pudong Hospital, Fudan UniversityGlioblastoma (GBM) is characterized by local and systemic immunosuppression, showing limited responses to immunotherapies. Here the authors describe the design of a nanoplatform composed of the lymphopenia alleviating agent cannabidiol and the lymphocyte recruiting cytokine LIGHT, promoting anti-tumor immune responses in GBM preclinical models.https://doi.org/10.1038/s41467-023-35957-8 |
| spellingShingle | Songlei Zhou Yukun Huang Yu Chen Yipu Liu Laozhi Xie Yang You Shiqiang Tong Jianpei Xu Gan Jiang Qingxiang Song Ni Mei Fenfen Ma Xiaoling Gao Hongzhuan Chen Jun Chen Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma Nature Communications |
| title | Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma |
| title_full | Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma |
| title_fullStr | Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma |
| title_full_unstemmed | Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma |
| title_short | Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma |
| title_sort | reprogramming systemic and local immune function to empower immunotherapy against glioblastoma |
| url | https://doi.org/10.1038/s41467-023-35957-8 |
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