Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract
Abstract Background Due to increased risk of pyelonephritis, patients with intestinal reconstruction of the lower urinary tract (IRLUT) have long been advised against kidney transplantation. The aim of this study was to compare the outcomes of transplantation between patients with IRLUT and patients...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | BJUI Compass |
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| Online Access: | https://doi.org/10.1002/bco2.105 |
| _version_ | 1819283180784451584 |
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| author | Juliette Gueguen Marc‐Olivier Timsit Anne Scemla Jean‐Michel Boutin Franck Bruyere Hélène Longuet Rebecca Sberro‐Soussan Christophe Legendre Dany Anglicheau Matthias Büchler |
| author_facet | Juliette Gueguen Marc‐Olivier Timsit Anne Scemla Jean‐Michel Boutin Franck Bruyere Hélène Longuet Rebecca Sberro‐Soussan Christophe Legendre Dany Anglicheau Matthias Büchler |
| author_sort | Juliette Gueguen |
| collection | DOAJ |
| description | Abstract Background Due to increased risk of pyelonephritis, patients with intestinal reconstruction of the lower urinary tract (IRLUT) have long been advised against kidney transplantation. The aim of this study was to compare the outcomes of transplantation between patients with IRLUT and patients with normal LUT (NLUT) using propensity score matching method. Methods The study included 23 kidney recipients with IRLUT matched to 46 kidney recipients with NLUT using known allograft survival and pyelonephritis risk factors as covariates. One‐, 5‐, and 10‐year graft survival, pyelonephritis, and surgical complications occurrence and graft function were compared. Results One‐, 5‐, and 10‐year graft survival were 96%, 91%, and 63% in the IRLUT group and 96%, 88%, and 70% in the NLUT group, respectively (p = 0.72). Patients with IRLUT had increased cumulative risk of pyelonephritis at 10 years (70% vs. 19%; log‐rank < 0.01) without impacting graft function or rejection occurrence. There was no difference in overall surgical complication, but patients with IRLUT had more urological complications than patients with NLUT (62% vs. 28%; p < 0.01). Conclusions Our case‐control study consolidates the results regarding the safety of transplantation in patients with IRLUT using a strong validated matching method and provides new insights regarding graft function, pyelonephritis, and surgical complications in this population. |
| first_indexed | 2024-12-24T01:27:23Z |
| format | Article |
| id | doaj.art-a48423548e324bc29fc6480abe6a5817 |
| institution | Directory Open Access Journal |
| issn | 2688-4526 |
| language | English |
| last_indexed | 2024-12-24T01:27:23Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | BJUI Compass |
| spelling | doaj.art-a48423548e324bc29fc6480abe6a58172022-12-21T17:22:27ZengWileyBJUI Compass2688-45262022-01-0131758510.1002/bco2.105Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tractJuliette Gueguen0Marc‐Olivier Timsit1Anne Scemla2Jean‐Michel Boutin3Franck Bruyere4Hélène Longuet5Rebecca Sberro‐Soussan6Christophe Legendre7Dany Anglicheau8Matthias Büchler9Department of Nephrology and Clinical Immunology Hospital of Tours Tours FranceDepartment of Urology and Renal Transplantation Georges Pompidou European Hospital, AP‐HP Paris FranceParis Cite and Kidney Transplantation Department Necker Hospital, Assistance Publique‐Hôpitaux de Paris, Paris Descartes University Sorbonne Paris FranceDepartment of Urology CHU de Tours Tours FranceTransplantation, Immunologie, Inflammation (T2I) University of Tours Tours FranceDepartment of Nephrology and Clinical Immunology Hospital of Tours Tours FranceParis Cite and Kidney Transplantation Department Necker Hospital, Assistance Publique‐Hôpitaux de Paris, Paris Descartes University Sorbonne Paris FranceParis Cite and Kidney Transplantation Department Necker Hospital, Assistance Publique‐Hôpitaux de Paris, Paris Descartes University Sorbonne Paris FranceParis Cite and Kidney Transplantation Department Necker Hospital, Assistance Publique‐Hôpitaux de Paris, Paris Descartes University Sorbonne Paris FranceDepartment of Nephrology and Clinical Immunology Hospital of Tours Tours FranceAbstract Background Due to increased risk of pyelonephritis, patients with intestinal reconstruction of the lower urinary tract (IRLUT) have long been advised against kidney transplantation. The aim of this study was to compare the outcomes of transplantation between patients with IRLUT and patients with normal LUT (NLUT) using propensity score matching method. Methods The study included 23 kidney recipients with IRLUT matched to 46 kidney recipients with NLUT using known allograft survival and pyelonephritis risk factors as covariates. One‐, 5‐, and 10‐year graft survival, pyelonephritis, and surgical complications occurrence and graft function were compared. Results One‐, 5‐, and 10‐year graft survival were 96%, 91%, and 63% in the IRLUT group and 96%, 88%, and 70% in the NLUT group, respectively (p = 0.72). Patients with IRLUT had increased cumulative risk of pyelonephritis at 10 years (70% vs. 19%; log‐rank < 0.01) without impacting graft function or rejection occurrence. There was no difference in overall surgical complication, but patients with IRLUT had more urological complications than patients with NLUT (62% vs. 28%; p < 0.01). Conclusions Our case‐control study consolidates the results regarding the safety of transplantation in patients with IRLUT using a strong validated matching method and provides new insights regarding graft function, pyelonephritis, and surgical complications in this population.https://doi.org/10.1002/bco2.105kidney allograft survivalkidney failurekidney transplantationsurgical complicationsurinary tract deviationurinary tract dysfunctions |
| spellingShingle | Juliette Gueguen Marc‐Olivier Timsit Anne Scemla Jean‐Michel Boutin Franck Bruyere Hélène Longuet Rebecca Sberro‐Soussan Christophe Legendre Dany Anglicheau Matthias Büchler Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract BJUI Compass kidney allograft survival kidney failure kidney transplantation surgical complications urinary tract deviation urinary tract dysfunctions |
| title | Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract |
| title_full | Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract |
| title_fullStr | Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract |
| title_full_unstemmed | Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract |
| title_short | Outcomes of kidney‐transplanted patients with history of intestinal reconstruction of the urinary tract |
| title_sort | outcomes of kidney transplanted patients with history of intestinal reconstruction of the urinary tract |
| topic | kidney allograft survival kidney failure kidney transplantation surgical complications urinary tract deviation urinary tract dysfunctions |
| url | https://doi.org/10.1002/bco2.105 |
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