Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway
IntroductionContinuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30–50% of patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches inte...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.879139/full |
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| author | Dominique V. M. Verhaert Dominique V. M. Verhaert Dominik Linz Dominik Linz Dominik Linz Dominik Linz Sevasti Maria Chaldoupi Sjoerd W. Westra Dennis W. den Uijl Suzanne Philippens Mijke Kerperien Zarina Habibi Zarina Habibi Bianca Vorstermans Rachel M. A. ter Bekke Rypko J. Beukema Reinder Evertz Martin E. W. Hemels Justin G. L. M. Luermans Justin G. L. M. Luermans Randolph Manusama Theo A. R. Lankveld Claudia A. J. van der Heijden Elham Bidar Ben J. M. Hermans Ben J. M. Hermans Stef Zeemering Geertruida P. Bijvoet Geertruida P. Bijvoet Jesse Habets Robert J. Holtackers Robert J. Holtackers Casper Mihl Robin Nijveldt Vanessa P. M. van Empel Christian Knackstedt Sami O. Simons Wolfgang F. F. A. Buhre Jan G. P. Tijssen Aaron Isaacs Harry J. G. M. Crijns Bart Maesen Kevin Vernooy Kevin Vernooy Ulrich Schotten |
| author_facet | Dominique V. M. Verhaert Dominique V. M. Verhaert Dominik Linz Dominik Linz Dominik Linz Dominik Linz Sevasti Maria Chaldoupi Sjoerd W. Westra Dennis W. den Uijl Suzanne Philippens Mijke Kerperien Zarina Habibi Zarina Habibi Bianca Vorstermans Rachel M. A. ter Bekke Rypko J. Beukema Reinder Evertz Martin E. W. Hemels Justin G. L. M. Luermans Justin G. L. M. Luermans Randolph Manusama Theo A. R. Lankveld Claudia A. J. van der Heijden Elham Bidar Ben J. M. Hermans Ben J. M. Hermans Stef Zeemering Geertruida P. Bijvoet Geertruida P. Bijvoet Jesse Habets Robert J. Holtackers Robert J. Holtackers Casper Mihl Robin Nijveldt Vanessa P. M. van Empel Christian Knackstedt Sami O. Simons Wolfgang F. F. A. Buhre Jan G. P. Tijssen Aaron Isaacs Harry J. G. M. Crijns Bart Maesen Kevin Vernooy Kevin Vernooy Ulrich Schotten |
| author_sort | Dominique V. M. Verhaert |
| collection | DOAJ |
| description | IntroductionContinuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30–50% of patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches integrated in clinical care pathways may improve our understanding of the complex pathophysiology of AF and improve patient selection for AF ablation.ObjectivesWithin the “IntenSive mOlecular and eLectropathological chAracterization of patienTs undergoIng atrial fibrillatiOn ablatioN” (ISOLATION) study, we aim to identify predictors of successful AF ablation in the following domains: (1) clinical factors, (2) AF patterns, (3) anatomical characteristics, (4) electrophysiological characteristics, (5) circulating biomarkers, and (6) genetic background. Herein, the design of the ISOLATION study and the integration of all study procedures into a standardized pathway for patients undergoing AF ablation are described.MethodsISOLATION (NCT04342312) is a two-center prospective cohort study including 650 patients undergoing AF ablation. Clinical characteristics and routine clinical test results will be collected, as well as results from the following additional diagnostics: determination of body composition, pre-procedural rhythm monitoring, extended surface electrocardiogram, biomarker testing, genetic analysis, and questionnaires. A multimodality model including a combination of established predictors and novel techniques will be developed to predict ablation success.DiscussionIn this study, several domains will be examined to identify predictors of successful AF ablation. The results may be used to improve patient selection for invasive AF management and to tailor treatment decisions to individual patients. |
| first_indexed | 2024-12-11T01:25:00Z |
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| id | doaj.art-a4857046cedb4b3ba1db6f6b80b721a5 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T01:25:00Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-a4857046cedb4b3ba1db6f6b80b721a52022-12-22T01:25:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-06-01910.3389/fcvm.2022.879139879139Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research PathwayDominique V. M. Verhaert0Dominique V. M. Verhaert1Dominik Linz2Dominik Linz3Dominik Linz4Dominik Linz5Sevasti Maria Chaldoupi6Sjoerd W. Westra7Dennis W. den Uijl8Suzanne Philippens9Mijke Kerperien10Zarina Habibi11Zarina Habibi12Bianca Vorstermans13Rachel M. A. ter Bekke14Rypko J. Beukema15Reinder Evertz16Martin E. W. Hemels17Justin G. L. M. Luermans18Justin G. L. M. Luermans19Randolph Manusama20Theo A. R. Lankveld21Claudia A. J. van der Heijden22Elham Bidar23Ben J. M. Hermans24Ben J. M. Hermans25Stef Zeemering26Geertruida P. Bijvoet27Geertruida P. Bijvoet28Jesse Habets29Robert J. Holtackers30Robert J. Holtackers31Casper Mihl32Robin Nijveldt33Vanessa P. M. van Empel34Christian Knackstedt35Sami O. Simons36Wolfgang F. F. A. Buhre37Jan G. P. Tijssen38Aaron Isaacs39Harry J. G. M. Crijns40Bart Maesen41Kevin Vernooy42Kevin Vernooy43Ulrich Schotten44Department of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsCentre for Heart Rhythm Disorders, Royal Adelaide Hospital, The University of Adelaide, Adelaide, SA, AustraliaDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, NetherlandsDepartment of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, NetherlandsDepartment of Radiology and Nuclear Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, NetherlandsSchool of Biomedical Engineering and Imaging Sciences, King’s College London, London, United KingdomDepartment of Radiology and Nuclear Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, Netherlands0Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, Netherlands1Department of Anesthesiology, Maastricht University Medical Center, Maastricht, Netherlands2Department of Cardiology, Amsterdam University Medical Center (UMC), Amsterdam, NetherlandsDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Cardiothoracic Surgery, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, NetherlandsDepartment of Cardiology, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, NetherlandsDepartment of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, NetherlandsDepartment of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, NetherlandsIntroductionContinuous progress in atrial fibrillation (AF) ablation techniques has led to an increasing number of procedures with improved outcome. However, about 30–50% of patients still experience recurrences within 1 year after their ablation. Comprehensive translational research approaches integrated in clinical care pathways may improve our understanding of the complex pathophysiology of AF and improve patient selection for AF ablation.ObjectivesWithin the “IntenSive mOlecular and eLectropathological chAracterization of patienTs undergoIng atrial fibrillatiOn ablatioN” (ISOLATION) study, we aim to identify predictors of successful AF ablation in the following domains: (1) clinical factors, (2) AF patterns, (3) anatomical characteristics, (4) electrophysiological characteristics, (5) circulating biomarkers, and (6) genetic background. Herein, the design of the ISOLATION study and the integration of all study procedures into a standardized pathway for patients undergoing AF ablation are described.MethodsISOLATION (NCT04342312) is a two-center prospective cohort study including 650 patients undergoing AF ablation. Clinical characteristics and routine clinical test results will be collected, as well as results from the following additional diagnostics: determination of body composition, pre-procedural rhythm monitoring, extended surface electrocardiogram, biomarker testing, genetic analysis, and questionnaires. A multimodality model including a combination of established predictors and novel techniques will be developed to predict ablation success.DiscussionIn this study, several domains will be examined to identify predictors of successful AF ablation. The results may be used to improve patient selection for invasive AF management and to tailor treatment decisions to individual patients.https://www.frontiersin.org/articles/10.3389/fcvm.2022.879139/fullatrial fibrillationcatheter ablationpulmonary vein isolationatrial fibrillation ablationstudy designtranslational research |
| spellingShingle | Dominique V. M. Verhaert Dominique V. M. Verhaert Dominik Linz Dominik Linz Dominik Linz Dominik Linz Sevasti Maria Chaldoupi Sjoerd W. Westra Dennis W. den Uijl Suzanne Philippens Mijke Kerperien Zarina Habibi Zarina Habibi Bianca Vorstermans Rachel M. A. ter Bekke Rypko J. Beukema Reinder Evertz Martin E. W. Hemels Justin G. L. M. Luermans Justin G. L. M. Luermans Randolph Manusama Theo A. R. Lankveld Claudia A. J. van der Heijden Elham Bidar Ben J. M. Hermans Ben J. M. Hermans Stef Zeemering Geertruida P. Bijvoet Geertruida P. Bijvoet Jesse Habets Robert J. Holtackers Robert J. Holtackers Casper Mihl Robin Nijveldt Vanessa P. M. van Empel Christian Knackstedt Sami O. Simons Wolfgang F. F. A. Buhre Jan G. P. Tijssen Aaron Isaacs Harry J. G. M. Crijns Bart Maesen Kevin Vernooy Kevin Vernooy Ulrich Schotten Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway Frontiers in Cardiovascular Medicine atrial fibrillation catheter ablation pulmonary vein isolation atrial fibrillation ablation study design translational research |
| title | Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway |
| title_full | Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway |
| title_fullStr | Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway |
| title_full_unstemmed | Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway |
| title_short | Rationale and Design of the ISOLATION Study: A Multicenter Prospective Cohort Study Identifying Predictors for Successful Atrial Fibrillation Ablation in an Integrated Clinical Care and Research Pathway |
| title_sort | rationale and design of the isolation study a multicenter prospective cohort study identifying predictors for successful atrial fibrillation ablation in an integrated clinical care and research pathway |
| topic | atrial fibrillation catheter ablation pulmonary vein isolation atrial fibrillation ablation study design translational research |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.879139/full |
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