Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages
We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-particip...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/37799 |
| _version_ | 1811181111404920832 |
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| author | Tineke Grent-'t-Jong Joachim Gross Jozien Goense Michael Wibral Ruchika Gajwani Andrew I Gumley Stephen M Lawrie Matthias Schwannauer Frauke Schultze-Lutter Tobias Navarro Schröder Dagmar Koethe F Markus Leweke Wolf Singer Peter J Uhlhaas |
| author_facet | Tineke Grent-'t-Jong Joachim Gross Jozien Goense Michael Wibral Ruchika Gajwani Andrew I Gumley Stephen M Lawrie Matthias Schwannauer Frauke Schultze-Lutter Tobias Navarro Schröder Dagmar Koethe F Markus Leweke Wolf Singer Peter J Uhlhaas |
| author_sort | Tineke Grent-'t-Jong |
| collection | DOAJ |
| description | We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ. |
| first_indexed | 2024-04-11T09:14:10Z |
| format | Article |
| id | doaj.art-a485f7b44ee442e3bf4e1185b8c949f7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:14:10Z |
| publishDate | 2018-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-a485f7b44ee442e3bf4e1185b8c949f72022-12-22T04:32:25ZengeLife Sciences Publications LtdeLife2050-084X2018-09-01710.7554/eLife.37799Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stagesTineke Grent-'t-Jong0https://orcid.org/0000-0003-3177-5346Joachim Gross1Jozien Goense2Michael Wibral3https://orcid.org/0000-0001-8010-5862Ruchika Gajwani4Andrew I Gumley5Stephen M Lawrie6https://orcid.org/0000-0002-2444-5675Matthias Schwannauer7https://orcid.org/0000-0002-4683-2596Frauke Schultze-Lutter8Tobias Navarro Schröder9https://orcid.org/0000-0001-6498-1846Dagmar Koethe10F Markus Leweke11https://orcid.org/0000-0002-8163-195XWolf Singer12https://orcid.org/0000-0002-8299-2319Peter J Uhlhaas13https://orcid.org/0000-0002-0892-2224Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, United KingdomInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, United Kingdom; Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, GermanyInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, United KingdomMEG-Unit, Goethe University, Frankfurt am Main, GermanyMental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, United KingdomMental Health and Wellbeing, Institute of Health and Wellbeing, University of Glasgow, Glasgow, United KingdomDepartment of Psychiatry, University of Edinburgh, Edinburgh, United KingdomDepartment of Clinical Psychology, University Edinburgh, Edinburgh, United KingdomUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, GermanyKavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Psychosomatics and Psychotherapeutic Medicine, Central Institute of Mental health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Brain and Mind Centre, University of Sydney, Sydney, AustraliaDepartment of Psychosomatics and Psychotherapeutic Medicine, Central Institute of Mental health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Brain and Mind Centre, University of Sydney, Sydney, Australia; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GermanyDepartment of Neurophysiology, Max Planck Institute for Brain Research, Frankfurt am Main, Germany; Ernst Strüngmann Institute for Neuroscience and the Max Planck Society, Frankfurt am Main, Germany; Frankfurt Institute for Advanced Studies, Frankfurt am Main, GermanyInstitute of Neuroscience and Psychology, University of Glasgow, Glasgow, United KingdomWe examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.https://elifesciences.org/articles/37799schizophreniaE/I-Balancegamma-band activity |
| spellingShingle | Tineke Grent-'t-Jong Joachim Gross Jozien Goense Michael Wibral Ruchika Gajwani Andrew I Gumley Stephen M Lawrie Matthias Schwannauer Frauke Schultze-Lutter Tobias Navarro Schröder Dagmar Koethe F Markus Leweke Wolf Singer Peter J Uhlhaas Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages eLife schizophrenia E/I-Balance gamma-band activity |
| title | Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages |
| title_full | Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages |
| title_fullStr | Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages |
| title_full_unstemmed | Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages |
| title_short | Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages |
| title_sort | resting state gamma band power alterations in schizophrenia reveal e i balance abnormalities across illness stages |
| topic | schizophrenia E/I-Balance gamma-band activity |
| url | https://elifesciences.org/articles/37799 |
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