Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis
Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and Fe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/8/12/182 |
| _version_ | 1827671877130125312 |
|---|---|
| author | Toshihide Izumida Teruhiko Imamura Makiko Nakamura Koichiro Kinugawa |
| author_facet | Toshihide Izumida Teruhiko Imamura Makiko Nakamura Koichiro Kinugawa |
| author_sort | Toshihide Izumida |
| collection | DOAJ |
| description | Background: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern. |
| first_indexed | 2024-03-10T03:51:51Z |
| format | Article |
| id | doaj.art-a486d5d3bca949758dc22eb142c729bb |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T03:51:51Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-a486d5d3bca949758dc22eb142c729bb2023-11-23T08:55:02ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-12-0181218210.3390/jcdd8120182Optimal Heart Rate and Prognosis in Patients with Cardiac AmyloidosisToshihide Izumida0Teruhiko Imamura1Makiko Nakamura2Koichiro Kinugawa3Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanSecond Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanSecond Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanSecond Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, JapanBackground: Optimal heart rate (HR) that associates with higher cardiac output and greater clinical outcomes in patients with cardiac amyloidosis remains unknown. Methods: Consecutive patients with sinus rhythm who were diagnosed with cardiac amyloidosis at our institute between February 2015 and February 2021 were retrospectively included. Ideal HR, at which E-wave and A-wave stand adjacent without any overlaps in the trans-mitral flow echocardiography, was calculated by the formula: 86.8−0.08 × deceleration time (msec). The association between optimal HR and cardiac death or heart failure readmission was investigated. Results: Ten patients (median 74 years old, 8 men) were included. On median, actual HR was 64 bpm and ideal HR was 69 bpm. An incidence rate of the primary endpoint in the sub-optimal HR group tended to be higher than optimal HR group: one of the four patients in optimal HR group had events (25%); two of the two patients in higher HR group had events (100%); two of the four patients in lower HR group had events (50%). Conclusions: The optimal HR was associated with greater clinical outcomes in patients with cardiac amyloidosis. The clinical impact of aggressive HR optimization in this cohort remains the next concern.https://www.mdpi.com/2308-3425/8/12/182ivabradinehemodynamicscardiac amyloidosis |
| spellingShingle | Toshihide Izumida Teruhiko Imamura Makiko Nakamura Koichiro Kinugawa Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis Journal of Cardiovascular Development and Disease ivabradine hemodynamics cardiac amyloidosis |
| title | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
| title_full | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
| title_fullStr | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
| title_full_unstemmed | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
| title_short | Optimal Heart Rate and Prognosis in Patients with Cardiac Amyloidosis |
| title_sort | optimal heart rate and prognosis in patients with cardiac amyloidosis |
| topic | ivabradine hemodynamics cardiac amyloidosis |
| url | https://www.mdpi.com/2308-3425/8/12/182 |
| work_keys_str_mv | AT toshihideizumida optimalheartrateandprognosisinpatientswithcardiacamyloidosis AT teruhikoimamura optimalheartrateandprognosisinpatientswithcardiacamyloidosis AT makikonakamura optimalheartrateandprognosisinpatientswithcardiacamyloidosis AT koichirokinugawa optimalheartrateandprognosisinpatientswithcardiacamyloidosis |