Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial
IntroductionThe aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two vari...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1155217/full |
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| author | Amar Arhab Nicolas Junod Nicolas Junod Nicolas Junod Jean-Benoit Rossel Olivier Giet Olivier Giet Frederic Sittarame Sandra Beer Daniela Sofra Dominique Durrer Humberto Delgado Montserrat Castellsague Markus Laimer Jardena J. Puder |
| author_facet | Amar Arhab Nicolas Junod Nicolas Junod Nicolas Junod Jean-Benoit Rossel Olivier Giet Olivier Giet Frederic Sittarame Sandra Beer Daniela Sofra Dominique Durrer Humberto Delgado Montserrat Castellsague Markus Laimer Jardena J. Puder |
| author_sort | Amar Arhab |
| collection | DOAJ |
| description | IntroductionThe aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two variants a different exercise frequencies on the same outcomes.Research design and methodsThis was a cluster randomized-controlled assessor-blind trial conducted in 11 clinical centres in Switzerland. All participants in the clinical program with type 2 diabetes were eligible and were randomized to either standard (3 sessions/week for 12 weeks) or alternative (1 session/week for the first four weeks, then 2 sessions/week for the rest of 16 weeks) physical activity program each consisting of 36 sessions of combined aerobic and resistance exercise. Allocation was concealed by a central office unrelated to the study. The primary outcome was aerobic fitness. Secondary outcome measures included: body composition, BMI, HbA1c, muscle strength, walking speed, balance, flexibility, blood pressure, lipid profile.ResultsAll 185 patients with type 2 diabetes (mean age 59.7 +-10.2 years, 48% women) agreed to participate and were randomized in two groups: a standard group (n=88) and an alternative group (n=97)). There was an 11% increase in aerobic fitness after the program (12.5 Watts; 95% CI 6.76 to 18.25; p<0.001). Significant improvements in physical fitness, body composition, and cardiometabolic parameters were observed at the end of the DIAfit program (improvements between 2-29%) except for lean body mass, triglycerides and cholesterol. No differences were observed between both programs, except for a larger weight reduction of -0.97kg (95% CI -0.04 to -1.91; p=0.04) in the standard program.ConclusionsBoth frequency variants of the nation-wide DIAfit program had beneficial effects on physical fitness, HbA1c, body composition, and blood pressure in type 2 diabetes patients and differences were negligible.Clinical trial registrationclinicaltrials.gov, identifier NCT01289587. |
| first_indexed | 2024-03-13T00:56:18Z |
| format | Article |
| id | doaj.art-a48717ff51e14b139a075f69b73dd540 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T00:56:18Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-a48717ff51e14b139a075f69b73dd5402023-07-06T21:22:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.11552171155217Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trialAmar Arhab0Nicolas Junod1Nicolas Junod2Nicolas Junod3Jean-Benoit Rossel4Olivier Giet5Olivier Giet6Frederic Sittarame7Sandra Beer8Daniela Sofra9Dominique Durrer10Humberto Delgado11Montserrat Castellsague12Markus Laimer13Jardena J. Puder14Obstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Lausanne, SwitzerlandObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Lausanne, SwitzerlandLa Lignière Clinic, Department of Medicine, Cardiovascular and Metabolic Rehabilitation Service, Gland, SwitzerlandLavaux Hospital, Cully, SwitzerlandObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Lausanne, SwitzerlandObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Lausanne, SwitzerlandSocio-medical Centre, Sierre, SwitzerlandCardiac Rehabilitation and Heart Failure Unity, Cardiology Service, Department of Medicine, University Hospitals Geneva, Geneva, SwitzerlandPrivate Practice for Diabetes and Endocrinology, Lausanne, SwitzerlandPrivate Practice for Diabetes and Endocrinology, Lausanne, SwitzerlandEuropean Association for the Study of Obesity (EASO), Collaborating Centre for Obesity Management (COMs), Vevey, SwitzerlandLa Lignière Clinic, Department of Medicine, Cardiovascular and Metabolic Rehabilitation Service, Gland, SwitzerlandDirection of Nursing Care, University Hospitals Geneva, Geneva, SwitzerlandDepartment of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital Bern University Hospital, Bern, SwitzerlandObstetric Service, Department Woman-Mother-Child, Lausanne University Hospital, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Lausanne, SwitzerlandIntroductionThe aim of this study was to evaluate the effectiveness of a real-life clinical physical activity program (DIAfit) on improving physical fitness, body composition, and cardiometabolic health in an unselected population with type 2 diabetes mellitus, and to compare the effects of two variants a different exercise frequencies on the same outcomes.Research design and methodsThis was a cluster randomized-controlled assessor-blind trial conducted in 11 clinical centres in Switzerland. All participants in the clinical program with type 2 diabetes were eligible and were randomized to either standard (3 sessions/week for 12 weeks) or alternative (1 session/week for the first four weeks, then 2 sessions/week for the rest of 16 weeks) physical activity program each consisting of 36 sessions of combined aerobic and resistance exercise. Allocation was concealed by a central office unrelated to the study. The primary outcome was aerobic fitness. Secondary outcome measures included: body composition, BMI, HbA1c, muscle strength, walking speed, balance, flexibility, blood pressure, lipid profile.ResultsAll 185 patients with type 2 diabetes (mean age 59.7 +-10.2 years, 48% women) agreed to participate and were randomized in two groups: a standard group (n=88) and an alternative group (n=97)). There was an 11% increase in aerobic fitness after the program (12.5 Watts; 95% CI 6.76 to 18.25; p<0.001). Significant improvements in physical fitness, body composition, and cardiometabolic parameters were observed at the end of the DIAfit program (improvements between 2-29%) except for lean body mass, triglycerides and cholesterol. No differences were observed between both programs, except for a larger weight reduction of -0.97kg (95% CI -0.04 to -1.91; p=0.04) in the standard program.ConclusionsBoth frequency variants of the nation-wide DIAfit program had beneficial effects on physical fitness, HbA1c, body composition, and blood pressure in type 2 diabetes patients and differences were negligible.Clinical trial registrationclinicaltrials.gov, identifier NCT01289587.https://www.frontiersin.org/articles/10.3389/fendo.2023.1155217/fulltype 2 diabetes mellitusaerobic fitnessbody compositionphysical activityrandomized clinical trial |
| spellingShingle | Amar Arhab Nicolas Junod Nicolas Junod Nicolas Junod Jean-Benoit Rossel Olivier Giet Olivier Giet Frederic Sittarame Sandra Beer Daniela Sofra Dominique Durrer Humberto Delgado Montserrat Castellsague Markus Laimer Jardena J. Puder Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial Frontiers in Endocrinology type 2 diabetes mellitus aerobic fitness body composition physical activity randomized clinical trial |
| title | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
| title_full | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
| title_fullStr | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
| title_full_unstemmed | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
| title_short | Effectiveness of a real-life program (DIAfit) to promote physical activity in patients with type 2 diabetes: a pragmatic cluster randomized clinical trial |
| title_sort | effectiveness of a real life program diafit to promote physical activity in patients with type 2 diabetes a pragmatic cluster randomized clinical trial |
| topic | type 2 diabetes mellitus aerobic fitness body composition physical activity randomized clinical trial |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1155217/full |
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