Intraocular siRNA Delivery Mediated by Penetratin Derivative to Silence Orthotopic Retinoblastoma Gene

Intraocular siRNA Delivery Mediated by Penetratin Derivative to Silence Orthotopic Retinoblastoma Gene

Gene therapy brings a ray of hope for inherited ocular diseases that may cause severe vision loss and even blindness. However, due to the dynamic and static absorption barriers, it is challenging to deliver genes to the posterior segment of the eye by topical instillation. To circumvent this limitat...

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Bibliographic Details
Main Authors: Xin Gao, Xingyan Fan, Kuan Jiang, Yang Hu, Yu Liu, Weiyue Lu, Gang Wei
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
gene delivery
intraocular drug delivery
siRNA
penetratin derivative
nonviral vector
noninvasive administration
Online Access:https://www.mdpi.com/1999-4923/15/3/745

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