Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature
Neoplastic diseases are rarely described in wild carnivores; only a few reports have been published on this topic. Here, we describe the histological and immunohistochemical features of a haemangioma in the spleen of a grey wolf (<i>Canis lupus lupus</i>) and we compare the results with...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/7/3/102 |
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| author | Josep Maria Monné Rodríguez Federico Morandi Paolo Cavicchio Alessandro Poli Ranieri Verin |
| author_facet | Josep Maria Monné Rodríguez Federico Morandi Paolo Cavicchio Alessandro Poli Ranieri Verin |
| author_sort | Josep Maria Monné Rodríguez |
| collection | DOAJ |
| description | Neoplastic diseases are rarely described in wild carnivores; only a few reports have been published on this topic. Here, we describe the histological and immunohistochemical features of a haemangioma in the spleen of a grey wolf (<i>Canis lupus lupus</i>) and we compare the results with the dog (<i>Canis lupus familiaris</i>). Additionally, we list the different publications found in the literature with neoplastic lesions in wolves. Our results show similar immunohistochemical features to dogs, in which neoplastic cells express Vimentin, von Willebrand factor, alpha smooth muscle actin antibody, vascular endothelial growth factor C and low vascular endothelial growth factor receptor 3. Toluidine blue special stain shows moderated increased numbers of mast cells infiltrating the tumor, a feature observed in benign vascular tumors in domestic dogs, but not in the malignant counterparts. To our knowledge, this is the first article describing the gross, histological and immunohistochemical features of a splenic haemangioma in a wolf. |
| first_indexed | 2024-03-10T18:00:14Z |
| format | Article |
| id | doaj.art-a487fed8b3e841b99985ad18cbe12d8f |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T18:00:14Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-a487fed8b3e841b99985ad18cbe12d8f2023-11-20T08:57:27ZengMDPI AGVeterinary Sciences2306-73812020-08-017310210.3390/vetsci7030102Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current LiteratureJosep Maria Monné Rodríguez0Federico Morandi1Paolo Cavicchio2Alessandro Poli3Ranieri Verin4Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 268, CH-8057 Zürich, SwitzerlandNational Park “Monti Sibillini” P.zza del Forno, 1 62039 Visso, ItalyPistoia Zoological Garden, Via Pieve a Celle Nuova, 160/A, 51100 Pistoia, ItalyDepartment of Veterinary Science, University of Pisa, 56124 Viale delle Piagge, 2 56124 Pisa, ItalyDepartment of Comparative Biomedicine and Food Science—University of Padova AGRIPOLIS—Viale dell’ Università 16, 35020 Legnaro, ItalyNeoplastic diseases are rarely described in wild carnivores; only a few reports have been published on this topic. Here, we describe the histological and immunohistochemical features of a haemangioma in the spleen of a grey wolf (<i>Canis lupus lupus</i>) and we compare the results with the dog (<i>Canis lupus familiaris</i>). Additionally, we list the different publications found in the literature with neoplastic lesions in wolves. Our results show similar immunohistochemical features to dogs, in which neoplastic cells express Vimentin, von Willebrand factor, alpha smooth muscle actin antibody, vascular endothelial growth factor C and low vascular endothelial growth factor receptor 3. Toluidine blue special stain shows moderated increased numbers of mast cells infiltrating the tumor, a feature observed in benign vascular tumors in domestic dogs, but not in the malignant counterparts. To our knowledge, this is the first article describing the gross, histological and immunohistochemical features of a splenic haemangioma in a wolf.https://www.mdpi.com/2306-7381/7/3/102european wolf (<i>Canis lupus lupus</i>)haemangiomahistopathologyimmunochistochemistryspleen |
| spellingShingle | Josep Maria Monné Rodríguez Federico Morandi Paolo Cavicchio Alessandro Poli Ranieri Verin Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature Veterinary Sciences european wolf (<i>Canis lupus lupus</i>) haemangioma histopathology immunochistochemistry spleen |
| title | Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature |
| title_full | Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature |
| title_fullStr | Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature |
| title_full_unstemmed | Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature |
| title_short | Morphological and Immunohistochemical Description of a Splenic Haemangioma in a Captive European Wolf (<i>Canis lupus lupus</i>) and a Review of the Current Literature |
| title_sort | morphological and immunohistochemical description of a splenic haemangioma in a captive european wolf i canis lupus lupus i and a review of the current literature |
| topic | european wolf (<i>Canis lupus lupus</i>) haemangioma histopathology immunochistochemistry spleen |
| url | https://www.mdpi.com/2306-7381/7/3/102 |
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