Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review
Introduction: Vaccine herd effects are the indirect protection that vaccinated persons provide to those who remain susceptible to infection, due to the reduced transmission of infections. Herd effects have been an important part of the discourse on how to best implement human papillomavirus (HPV) va...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-05-01
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| Series: | Expert Review of Vaccines |
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| Online Access: | http://dx.doi.org/10.1080/14760584.2018.1471986 |
| _version_ | 1797680438043475968 |
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| author | Talía Malagón Cassandra Laurie Eduardo L. Franco |
| author_facet | Talía Malagón Cassandra Laurie Eduardo L. Franco |
| author_sort | Talía Malagón |
| collection | DOAJ |
| description | Introduction: Vaccine herd effects are the indirect protection that vaccinated persons provide to those who remain susceptible to infection, due to the reduced transmission of infections. Herd effects have been an important part of the discourse on how to best implement human papillomavirus (HPV) vaccines and prevent HPV-related diseases. Areas covered: In this paper, we review the theory of HPV vaccine herd effects derived from mathematical models, give an account of observed HPV vaccine herd effects worldwide, and examine the implications of vaccine herd effects for future cervical cancer screening efforts. Expert commentary: HPV vaccine herd effects improve the cost-effectiveness of vaccinating preadolescent girls, but contribute to making gender-neutral vaccination less economically efficient. Vaccination coverage and sexual mixing patterns by age are strong determinants of herd effects. Many countries worldwide are starting to observe reductions in HPV-related outcomes likely attributable to herd effects, most notably declining anogenital warts in young men, and declining HPV-16/18 infection prevalence in young unvaccinated women. Policy makers making recommendations for cervical cancer screening will have to consider HPV vaccination coverage and herd effects, as these will affect the positive predictive value of screening and the risk of cervical cancer in unvaccinated women. |
| first_indexed | 2024-03-11T23:30:02Z |
| format | Article |
| id | doaj.art-a489008189f440a6a1d9940b30c8e8d6 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:30:02Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-a489008189f440a6a1d9940b30c8e8d62023-09-20T10:18:03ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952018-05-0117539540910.1080/14760584.2018.14719861471986Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a reviewTalía Malagón0Cassandra Laurie1Eduardo L. Franco2McGill UniversityMcGill UniversityMcGill UniversityIntroduction: Vaccine herd effects are the indirect protection that vaccinated persons provide to those who remain susceptible to infection, due to the reduced transmission of infections. Herd effects have been an important part of the discourse on how to best implement human papillomavirus (HPV) vaccines and prevent HPV-related diseases. Areas covered: In this paper, we review the theory of HPV vaccine herd effects derived from mathematical models, give an account of observed HPV vaccine herd effects worldwide, and examine the implications of vaccine herd effects for future cervical cancer screening efforts. Expert commentary: HPV vaccine herd effects improve the cost-effectiveness of vaccinating preadolescent girls, but contribute to making gender-neutral vaccination less economically efficient. Vaccination coverage and sexual mixing patterns by age are strong determinants of herd effects. Many countries worldwide are starting to observe reductions in HPV-related outcomes likely attributable to herd effects, most notably declining anogenital warts in young men, and declining HPV-16/18 infection prevalence in young unvaccinated women. Policy makers making recommendations for cervical cancer screening will have to consider HPV vaccination coverage and herd effects, as these will affect the positive predictive value of screening and the risk of cervical cancer in unvaccinated women.http://dx.doi.org/10.1080/14760584.2018.1471986anogenital wartseffectivenessherd effectsherd immunityhpv infectionhuman papillomavirusvaccinationvaccine |
| spellingShingle | Talía Malagón Cassandra Laurie Eduardo L. Franco Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review Expert Review of Vaccines anogenital warts effectiveness herd effects herd immunity hpv infection human papillomavirus vaccination vaccine |
| title | Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review |
| title_full | Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review |
| title_fullStr | Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review |
| title_full_unstemmed | Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review |
| title_short | Human papillomavirus vaccination and the role of herd effects in future cancer control planning: a review |
| title_sort | human papillomavirus vaccination and the role of herd effects in future cancer control planning a review |
| topic | anogenital warts effectiveness herd effects herd immunity hpv infection human papillomavirus vaccination vaccine |
| url | http://dx.doi.org/10.1080/14760584.2018.1471986 |
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