Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-77415-1 |
| _version_ | 1818682688830177280 |
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| author | Katsunori Yokoi Makoto Hattori Yuki Satake Yasuhiro Tanaka Maki Sato Atsushi Hashizume Akihiro Hori Motoshi Kawashima Akihiro Hirakawa Hirohisa Watanabe Masahisa Katsuno |
| author_facet | Katsunori Yokoi Makoto Hattori Yuki Satake Yasuhiro Tanaka Maki Sato Atsushi Hashizume Akihiro Hori Motoshi Kawashima Akihiro Hirakawa Hirohisa Watanabe Masahisa Katsuno |
| author_sort | Katsunori Yokoi |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health check-up data before and after the onset of motor symptoms between male and female PD patients and healthy subjects. We enrolled 22 male and 23 female PD patients and 60 male and 60 female healthy controls. A mixed-effects model was used to estimate the trajectory of each clinical marker over the years before and after motor symptoms onset in the PD subjects, which were then compared with the trajectories of the healthy controls. The results showed a premotor blood pressure increase in female PD patients and premotor decreases in haematocrit, total cholesterol and low-density lipoprotein cholesterol in the male patients. Our results indicated that blood pressure, haematocrit and serum cholesterol levels are potential premotor markers of PD. Additionally, the changes in anthropometric and serological indices before PD motor symptoms onset were sex specific. |
| first_indexed | 2024-12-17T10:22:50Z |
| format | Article |
| id | doaj.art-a48ab8e8097144e7b966d67d9ef7b238 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T10:22:50Z |
| publishDate | 2020-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a48ab8e8097144e7b966d67d9ef7b2382022-12-21T21:52:44ZengNature PortfolioScientific Reports2045-23222020-11-0110111010.1038/s41598-020-77415-1Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s diseaseKatsunori Yokoi0Makoto Hattori1Yuki Satake2Yasuhiro Tanaka3Maki Sato4Atsushi Hashizume5Akihiro Hori6Motoshi Kawashima7Akihiro Hirakawa8Hirohisa Watanabe9Masahisa Katsuno10Department of Neurology, Nagoya University Graduate School of MedicineDepartment of Neurology, Nagoya University Graduate School of MedicineDepartment of Neurology, Nagoya University Graduate School of MedicineDepartment of Neurology, Nagoya University Graduate School of MedicineDepartment of Neurology, Nagoya University Graduate School of MedicineDepartment of Neurology, Nagoya University Graduate School of MedicineKumiai Kosei HospitalMedical Examination Centre, Daido ClinicDepartment of Clinical Biostatistics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental UniversityBrain & Mind Research Centre, Nagoya University Graduate School of MedicineDepartment of Neurology, Nagoya University Graduate School of MedicineAbstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health check-up data before and after the onset of motor symptoms between male and female PD patients and healthy subjects. We enrolled 22 male and 23 female PD patients and 60 male and 60 female healthy controls. A mixed-effects model was used to estimate the trajectory of each clinical marker over the years before and after motor symptoms onset in the PD subjects, which were then compared with the trajectories of the healthy controls. The results showed a premotor blood pressure increase in female PD patients and premotor decreases in haematocrit, total cholesterol and low-density lipoprotein cholesterol in the male patients. Our results indicated that blood pressure, haematocrit and serum cholesterol levels are potential premotor markers of PD. Additionally, the changes in anthropometric and serological indices before PD motor symptoms onset were sex specific.https://doi.org/10.1038/s41598-020-77415-1 |
| spellingShingle | Katsunori Yokoi Makoto Hattori Yuki Satake Yasuhiro Tanaka Maki Sato Atsushi Hashizume Akihiro Hori Motoshi Kawashima Akihiro Hirakawa Hirohisa Watanabe Masahisa Katsuno Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease Scientific Reports |
| title | Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease |
| title_full | Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease |
| title_fullStr | Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease |
| title_full_unstemmed | Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease |
| title_short | Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease |
| title_sort | longitudinal analysis of premotor anthropometric and serological markers of parkinson s disease |
| url | https://doi.org/10.1038/s41598-020-77415-1 |
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