Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction
Background: We aimed to explore whether transcranial Doppler (TCD) combined with quantitative electroencephalography (QEEG) can improve prognosis evaluation in patients with a large hemispheric infarction (LHI) and to establish an accurate prognosis prediction model.Methods: We prospectively assesse...
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2021.724571/full |
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| author | Yajie Qi Yajie Qi Yingqi Xing Yingqi Xing Lijuan Wang Jie Zhang Yanting Cao Yanting Cao Li Liu Li Liu Ying Chen |
| author_facet | Yajie Qi Yajie Qi Yingqi Xing Yingqi Xing Lijuan Wang Jie Zhang Yanting Cao Yanting Cao Li Liu Li Liu Ying Chen |
| author_sort | Yajie Qi |
| collection | DOAJ |
| description | Background: We aimed to explore whether transcranial Doppler (TCD) combined with quantitative electroencephalography (QEEG) can improve prognosis evaluation in patients with a large hemispheric infarction (LHI) and to establish an accurate prognosis prediction model.Methods: We prospectively assessed 90-day mortality in patients with LHI. Brain function was monitored using TCD-QEEG at the bedside of the patient.Results: Of the 59 (55.3 ± 10.6 years; 17 men) enrolled patients, 37 (67.3%) patients died within 90 days. The Cox regression analyses revealed that the Glasgow Coma Scale (GCS) score ≤ 8 [hazard ratio (HR), 3.228; 95% CI, 1.335–7.801; p = 0.009], TCD-terminal internal carotid artery as the offending vessel (HR, 3.830; 95% CI, 1.301–11.271; p = 0.015), and QEEG-a (delta + theta)/(alpha + beta) ratio ≥ 3 (HR, 3.647; 95% CI, 1.170–11.373; p = 0.026) independently predicted survival duration. Combining these three factors yielded an area under the receiver operating characteristic curve of 0.905 and had better predictive accuracy than those of individual variables (p < 0.05).Conclusion: TCD and QEEG complement the GCS score to create a reliable multimodal method for monitoring prognosis in patients with LHI. |
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| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-14T07:30:33Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-a48d167ac787421fb6c26c8c8e4667122022-12-21T23:11:22ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-12-011210.3389/fneur.2021.724571724571Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis PredictionYajie Qi0Yajie Qi1Yingqi Xing2Yingqi Xing3Lijuan Wang4Jie Zhang5Yanting Cao6Yanting Cao7Li Liu8Li Liu9Ying Chen10Department of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurosurgery, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, ChinaDepartment of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Diagnostic Center of Vascular Ultrasound, Beijing, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, Linyi People's Hospital, Linyi, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, Changchun People's Hospital, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaBackground: We aimed to explore whether transcranial Doppler (TCD) combined with quantitative electroencephalography (QEEG) can improve prognosis evaluation in patients with a large hemispheric infarction (LHI) and to establish an accurate prognosis prediction model.Methods: We prospectively assessed 90-day mortality in patients with LHI. Brain function was monitored using TCD-QEEG at the bedside of the patient.Results: Of the 59 (55.3 ± 10.6 years; 17 men) enrolled patients, 37 (67.3%) patients died within 90 days. The Cox regression analyses revealed that the Glasgow Coma Scale (GCS) score ≤ 8 [hazard ratio (HR), 3.228; 95% CI, 1.335–7.801; p = 0.009], TCD-terminal internal carotid artery as the offending vessel (HR, 3.830; 95% CI, 1.301–11.271; p = 0.015), and QEEG-a (delta + theta)/(alpha + beta) ratio ≥ 3 (HR, 3.647; 95% CI, 1.170–11.373; p = 0.026) independently predicted survival duration. Combining these three factors yielded an area under the receiver operating characteristic curve of 0.905 and had better predictive accuracy than those of individual variables (p < 0.05).Conclusion: TCD and QEEG complement the GCS score to create a reliable multimodal method for monitoring prognosis in patients with LHI.https://www.frontiersin.org/articles/10.3389/fneur.2021.724571/fullglasgow coma scalelarge hemispheric infarctionmultimodal monitoringprognosisquantitative electroencephalographytranscranial doppler |
| spellingShingle | Yajie Qi Yajie Qi Yingqi Xing Yingqi Xing Lijuan Wang Jie Zhang Yanting Cao Yanting Cao Li Liu Li Liu Ying Chen Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction Frontiers in Neurology glasgow coma scale large hemispheric infarction multimodal monitoring prognosis quantitative electroencephalography transcranial doppler |
| title | Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction |
| title_full | Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction |
| title_fullStr | Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction |
| title_full_unstemmed | Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction |
| title_short | Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction |
| title_sort | multimodal monitoring in large hemispheric infarction quantitative electroencephalography combined with transcranial doppler for prognosis prediction |
| topic | glasgow coma scale large hemispheric infarction multimodal monitoring prognosis quantitative electroencephalography transcranial doppler |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2021.724571/full |
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