A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis
Infective endocarditis (IE) is a rare but severe disease with high morbidity and mortality. Cardiac surgery plays a major role in the contemporary clinical management of IE patients. During cardiac surgery, cardiopulmonary bypass significantly contributes to an increased risk of organ dysfunction an...
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| Format: | Article |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/3/763 |
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| author | Anan Gong Yupei Li Mei Yang Shujing Wang Baihai Su |
| author_facet | Anan Gong Yupei Li Mei Yang Shujing Wang Baihai Su |
| author_sort | Anan Gong |
| collection | DOAJ |
| description | Infective endocarditis (IE) is a rare but severe disease with high morbidity and mortality. Cardiac surgery plays a major role in the contemporary clinical management of IE patients. During cardiac surgery, cardiopulmonary bypass significantly contributes to an increased risk of organ dysfunction and mortality by inducing an acute inflammatory response, vascular endothelial cell injury, impairment of the coagulation cascade, and ischemia–reperfusion injury. During the past decade, the use of extracorporeal hemoadsorption therapy with the CytoSorb<sup>®</sup> hemoadsorber (CytoSorbents Europe GmbH, Berlin, Germany) has been proposed as an adjuvant therapy to mediate inflammatory responses in IE patients undergoing cardiac surgery with cardiopulmonary bypass. However, there is currently no systematic evaluation of the effect of CytoSorb<sup>®</sup> hemoadsorption on clinical outcomes such as hemodynamics, organ dysfunction, and mortality in patients with IE. Therefore, in this review, we exclusively discuss contemporary findings concerning the rationale, clinical evidence, and future perspectives for CytoSorb<sup>®</sup> hemoadsorption therapy in IE patients. |
| first_indexed | 2024-03-08T03:53:54Z |
| format | Article |
| id | doaj.art-a48d701ae3a04abcb683b3eb5c220a28 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:53:54Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-a48d701ae3a04abcb683b3eb5c220a282024-02-09T15:15:56ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113376310.3390/jcm13030763A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective EndocarditisAnan Gong0Yupei Li1Mei Yang2Shujing Wang3Baihai Su4Department of Nephrology, Kidney Research Institute, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nephrology, Kidney Research Institute, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaGeneral Practice Ward/International Medical Center Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nephrology, Kidney Research Institute, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaDepartment of Nephrology, Kidney Research Institute, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, ChinaInfective endocarditis (IE) is a rare but severe disease with high morbidity and mortality. Cardiac surgery plays a major role in the contemporary clinical management of IE patients. During cardiac surgery, cardiopulmonary bypass significantly contributes to an increased risk of organ dysfunction and mortality by inducing an acute inflammatory response, vascular endothelial cell injury, impairment of the coagulation cascade, and ischemia–reperfusion injury. During the past decade, the use of extracorporeal hemoadsorption therapy with the CytoSorb<sup>®</sup> hemoadsorber (CytoSorbents Europe GmbH, Berlin, Germany) has been proposed as an adjuvant therapy to mediate inflammatory responses in IE patients undergoing cardiac surgery with cardiopulmonary bypass. However, there is currently no systematic evaluation of the effect of CytoSorb<sup>®</sup> hemoadsorption on clinical outcomes such as hemodynamics, organ dysfunction, and mortality in patients with IE. Therefore, in this review, we exclusively discuss contemporary findings concerning the rationale, clinical evidence, and future perspectives for CytoSorb<sup>®</sup> hemoadsorption therapy in IE patients.https://www.mdpi.com/2077-0383/13/3/763hemoadsorptioninfective endocarditisCytoSorb<sup>®</sup>cardiopulmonary bypasscardiac surgerymortality |
| spellingShingle | Anan Gong Yupei Li Mei Yang Shujing Wang Baihai Su A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis Journal of Clinical Medicine hemoadsorption infective endocarditis CytoSorb<sup>®</sup> cardiopulmonary bypass cardiac surgery mortality |
| title | A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis |
| title_full | A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis |
| title_fullStr | A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis |
| title_full_unstemmed | A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis |
| title_short | A Contemporary Review of the Use of Extracorporeal CytoSorb<sup>®</sup> Hemoadsorption Therapy in Patients with Infective Endocarditis |
| title_sort | contemporary review of the use of extracorporeal cytosorb sup r sup hemoadsorption therapy in patients with infective endocarditis |
| topic | hemoadsorption infective endocarditis CytoSorb<sup>®</sup> cardiopulmonary bypass cardiac surgery mortality |
| url | https://www.mdpi.com/2077-0383/13/3/763 |
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