Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study.
BACKGROUND: This study presents an evaluation of the bidirectional correlation between attention deficit hyperactivity disorder (ADHD) and epilepsy using 2 cohorts from the same population database. METHODS: We used data from the Taiwan National Health Insurance Research Database to establish 2 sepa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3590288?pdf=render |
| _version_ | 1819113870962196480 |
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| author | I-Ching Chou Yu-Tzu Chang Zheng-Nan Chin Chih-Hsin Muo Fung-Chang Sung Huang-Tsung Kuo Chang-Hai Tsai Chia-Hung Kao |
| author_facet | I-Ching Chou Yu-Tzu Chang Zheng-Nan Chin Chih-Hsin Muo Fung-Chang Sung Huang-Tsung Kuo Chang-Hai Tsai Chia-Hung Kao |
| author_sort | I-Ching Chou |
| collection | DOAJ |
| description | BACKGROUND: This study presents an evaluation of the bidirectional correlation between attention deficit hyperactivity disorder (ADHD) and epilepsy using 2 cohorts from the same population database. METHODS: We used data from the Taiwan National Health Insurance Research Database to establish 2 separate cohort studies with participants <19 years old. We subdivided Cohort 1 in 2 groups: (1) 2468 patients initially diagnosed with epilepsy during the period 1999-2008, and (2) 9810 randomly selected sex- and age-matched non-epileptic controls. We subdivided Cohort 2 into 2 groups: (1) 3664 patients with newly diagnosed ADHD and (2) 14 522 sex- and age-matched non-ADHD patients. We evaluated the risk of subsequent ADHD in relationship to epilepsy and vice versa in the 2 cohorts at the end of 2008. RESULTS: The ADHD incidence in Cohort 1 was 7.76 in patients with epilepsy and 3.22 in those without epilepsy (per 1000 person-years) after a median follow-up of 7-7.5 years. The adjusted hazard ratio (HR) for ADHD was 2.54 (95% CI 2.02-3.18) in the epilepsy group compared to the non-epilepsy group. In Cohort 2, the incidence of epilepsy was 3.24 in patients with ADHD and 0.78 in those without ADHD (per 1000 person-years) after a median follow-up of 3-3.5 years and an HR of 3.94 (95% CI 2.58-6.03). CONCLUSION: This study shows a bidirectional association between ADHD and epilepsy in the 2 cohort studies. Causative factors may be common between these 2 disorders, leading to a cascade of transcriptional changes in the brain that alter behavior or cognition prior to seizures. |
| first_indexed | 2024-12-22T04:36:17Z |
| format | Article |
| id | doaj.art-a48d94e75c30484bba22f176f9bdb932 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T04:36:17Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a48d94e75c30484bba22f176f9bdb9322022-12-21T18:38:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5792610.1371/journal.pone.0057926Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study.I-Ching ChouYu-Tzu ChangZheng-Nan ChinChih-Hsin MuoFung-Chang SungHuang-Tsung KuoChang-Hai TsaiChia-Hung KaoBACKGROUND: This study presents an evaluation of the bidirectional correlation between attention deficit hyperactivity disorder (ADHD) and epilepsy using 2 cohorts from the same population database. METHODS: We used data from the Taiwan National Health Insurance Research Database to establish 2 separate cohort studies with participants <19 years old. We subdivided Cohort 1 in 2 groups: (1) 2468 patients initially diagnosed with epilepsy during the period 1999-2008, and (2) 9810 randomly selected sex- and age-matched non-epileptic controls. We subdivided Cohort 2 into 2 groups: (1) 3664 patients with newly diagnosed ADHD and (2) 14 522 sex- and age-matched non-ADHD patients. We evaluated the risk of subsequent ADHD in relationship to epilepsy and vice versa in the 2 cohorts at the end of 2008. RESULTS: The ADHD incidence in Cohort 1 was 7.76 in patients with epilepsy and 3.22 in those without epilepsy (per 1000 person-years) after a median follow-up of 7-7.5 years. The adjusted hazard ratio (HR) for ADHD was 2.54 (95% CI 2.02-3.18) in the epilepsy group compared to the non-epilepsy group. In Cohort 2, the incidence of epilepsy was 3.24 in patients with ADHD and 0.78 in those without ADHD (per 1000 person-years) after a median follow-up of 3-3.5 years and an HR of 3.94 (95% CI 2.58-6.03). CONCLUSION: This study shows a bidirectional association between ADHD and epilepsy in the 2 cohort studies. Causative factors may be common between these 2 disorders, leading to a cascade of transcriptional changes in the brain that alter behavior or cognition prior to seizures.http://europepmc.org/articles/PMC3590288?pdf=render |
| spellingShingle | I-Ching Chou Yu-Tzu Chang Zheng-Nan Chin Chih-Hsin Muo Fung-Chang Sung Huang-Tsung Kuo Chang-Hai Tsai Chia-Hung Kao Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. PLoS ONE |
| title | Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. |
| title_full | Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. |
| title_fullStr | Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. |
| title_full_unstemmed | Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. |
| title_short | Correlation between epilepsy and attention deficit hyperactivity disorder: a population-based cohort study. |
| title_sort | correlation between epilepsy and attention deficit hyperactivity disorder a population based cohort study |
| url | http://europepmc.org/articles/PMC3590288?pdf=render |
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