The Advancing Roles of Exosomes in Breast Cancer
Breast cancer (BC) develops from breast tissue and is the most common aggressive malignant tumor in women worldwide. Although advanced treatment strategies have been applied and reduced current mortality rates, BC control remains unsatisfactory. It is essential to elucidate the underlying molecular...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.731062/full |
| _version_ | 1818724209260494848 |
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| author | Xi Wang Xi Wang Chunxiao Sun Xiang Huang Jun Li Ziyi Fu Ziyi Fu Wei Li Yongmei Yin |
| author_facet | Xi Wang Xi Wang Chunxiao Sun Xiang Huang Jun Li Ziyi Fu Ziyi Fu Wei Li Yongmei Yin |
| author_sort | Xi Wang |
| collection | DOAJ |
| description | Breast cancer (BC) develops from breast tissue and is the most common aggressive malignant tumor in women worldwide. Although advanced treatment strategies have been applied and reduced current mortality rates, BC control remains unsatisfactory. It is essential to elucidate the underlying molecular mechanisms to assist clinical options. Exosomes are a type of extracellular vesicles and mediate cellular communications by delivering various biomolecules (oncogenes, oncomiRs, proteins, and even pharmacological compounds). These bioactive molecules can be transferred to change the transcriptome of target cells and influence tumor-related signaling pathways. Extensive studies have implicated exosomes in BC biology, including therapeutic resistance and the surrounding microenvironment. This review focuses on discussing the functions of exosomes in tumor treatment resistance, invasion and metastasis of BC. Moreover, we will also summarize multiple interactions between exosomes and the BC tumor microenvironment. Finally, we propose promising clinical applications of exosomes in BC. |
| first_indexed | 2024-12-17T21:22:46Z |
| format | Article |
| id | doaj.art-a48df4927062482cbfe77557d4a3f58a |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T21:22:46Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-a48df4927062482cbfe77557d4a3f58a2022-12-21T21:32:08ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.731062731062The Advancing Roles of Exosomes in Breast CancerXi Wang0Xi Wang1Chunxiao Sun2Xiang Huang3Jun Li4Ziyi Fu5Ziyi Fu6Wei Li7Yongmei Yin8Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaThe First School of Clinical Medicine, Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaNanjing Maternity and Child Medical Institute, Obstetrics and Gynecology Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaBreast cancer (BC) develops from breast tissue and is the most common aggressive malignant tumor in women worldwide. Although advanced treatment strategies have been applied and reduced current mortality rates, BC control remains unsatisfactory. It is essential to elucidate the underlying molecular mechanisms to assist clinical options. Exosomes are a type of extracellular vesicles and mediate cellular communications by delivering various biomolecules (oncogenes, oncomiRs, proteins, and even pharmacological compounds). These bioactive molecules can be transferred to change the transcriptome of target cells and influence tumor-related signaling pathways. Extensive studies have implicated exosomes in BC biology, including therapeutic resistance and the surrounding microenvironment. This review focuses on discussing the functions of exosomes in tumor treatment resistance, invasion and metastasis of BC. Moreover, we will also summarize multiple interactions between exosomes and the BC tumor microenvironment. Finally, we propose promising clinical applications of exosomes in BC.https://www.frontiersin.org/articles/10.3389/fcell.2021.731062/fullexosomesbreast cancertumor microenvironmentresistanceclinical applications |
| spellingShingle | Xi Wang Xi Wang Chunxiao Sun Xiang Huang Jun Li Ziyi Fu Ziyi Fu Wei Li Yongmei Yin The Advancing Roles of Exosomes in Breast Cancer Frontiers in Cell and Developmental Biology exosomes breast cancer tumor microenvironment resistance clinical applications |
| title | The Advancing Roles of Exosomes in Breast Cancer |
| title_full | The Advancing Roles of Exosomes in Breast Cancer |
| title_fullStr | The Advancing Roles of Exosomes in Breast Cancer |
| title_full_unstemmed | The Advancing Roles of Exosomes in Breast Cancer |
| title_short | The Advancing Roles of Exosomes in Breast Cancer |
| title_sort | advancing roles of exosomes in breast cancer |
| topic | exosomes breast cancer tumor microenvironment resistance clinical applications |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.731062/full |
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