Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
Abstract There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI)...
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| Format: | Article |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80014-9 |
| _version_ | 1818851297997094912 |
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| author | Yong Dae Kim Jun Yup Kim Young Joo Park Sang Jun Park Sung Hyun Baik Jihoon Kang Cheolkyu Jung Se Joon Woo |
| author_facet | Yong Dae Kim Jun Yup Kim Young Joo Park Sang Jun Park Sung Hyun Baik Jihoon Kang Cheolkyu Jung Se Joon Woo |
| author_sort | Yong Dae Kim |
| collection | DOAJ |
| description | Abstract There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI) in patients with newly diagnosed NA-RAO. In this retrospective, observational, case-series study, consecutive patients with NA-RAO who underwent cerebral MRI within one month of diagnosis between September 2003 and October 2018 were included. The classification of NA-RAO was based on ophthalmologic and systemic examinations. We also investigated the co-incident infarction and burden of underlying SVD, which were categorized as white matter hyperintensity lesion (WMH), cerebral microbleeds (CMB), and silent lacunar infarction (SLI). Among the 272 patients enrolled in the study, 18% presented co-incident infarction and 73% had SVD, which included WMH (70%), CMB (14%), and SLI (30%). Co-incident infarction, WMH, and SLI significantly increased with age: co-incident infarction was observed in 8% of young (< 50 years) patients and 30% of old (≥ 70 years) patients. The embolic etiology of RAO (large artery atherosclerosis, cardioembolism, and undetermined etiology) was significantly associated with the prevalence of SVD (82%: 70%: 64%, P = 0.002) and co-incident infarction (30%: 19%: 8%; P = 0.009). Therefore, high co-incidence of acute cerebral infarction and underlying SVD burden warrant careful neurologic examination and appropriate brain imaging, followed by management of NA-RAO. Urgent brain imaging is particularly pertinent in elderly patients with NA-RAO. |
| first_indexed | 2024-12-19T07:02:48Z |
| format | Article |
| id | doaj.art-a48f728c8a50436da440d6ff6a092f34 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T07:02:48Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-a48f728c8a50436da440d6ff6a092f342022-12-21T20:31:23ZengNature PortfolioScientific Reports2045-23222021-01-0111111210.1038/s41598-020-80014-9Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusionYong Dae Kim0Jun Yup Kim1Young Joo Park2Sang Jun Park3Sung Hyun Baik4Jihoon Kang5Cheolkyu Jung6Se Joon Woo7Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang HospitalDepartment of Radiology, Seoul National University College of Medicine, Seoul National University Bundang HospitalDepartment of Ophthalmology, Kangwon National University HospitalDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang HospitalDepartment of Radiology, Seoul National University College of Medicine, Seoul National University Bundang HospitalDepartment of Neurology, Seoul National University College of Medicine, Seoul National University Bundang HospitalDepartment of Radiology, Seoul National University College of Medicine, Seoul National University Bundang HospitalDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang HospitalAbstract There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI) in patients with newly diagnosed NA-RAO. In this retrospective, observational, case-series study, consecutive patients with NA-RAO who underwent cerebral MRI within one month of diagnosis between September 2003 and October 2018 were included. The classification of NA-RAO was based on ophthalmologic and systemic examinations. We also investigated the co-incident infarction and burden of underlying SVD, which were categorized as white matter hyperintensity lesion (WMH), cerebral microbleeds (CMB), and silent lacunar infarction (SLI). Among the 272 patients enrolled in the study, 18% presented co-incident infarction and 73% had SVD, which included WMH (70%), CMB (14%), and SLI (30%). Co-incident infarction, WMH, and SLI significantly increased with age: co-incident infarction was observed in 8% of young (< 50 years) patients and 30% of old (≥ 70 years) patients. The embolic etiology of RAO (large artery atherosclerosis, cardioembolism, and undetermined etiology) was significantly associated with the prevalence of SVD (82%: 70%: 64%, P = 0.002) and co-incident infarction (30%: 19%: 8%; P = 0.009). Therefore, high co-incidence of acute cerebral infarction and underlying SVD burden warrant careful neurologic examination and appropriate brain imaging, followed by management of NA-RAO. Urgent brain imaging is particularly pertinent in elderly patients with NA-RAO.https://doi.org/10.1038/s41598-020-80014-9 |
| spellingShingle | Yong Dae Kim Jun Yup Kim Young Joo Park Sang Jun Park Sung Hyun Baik Jihoon Kang Cheolkyu Jung Se Joon Woo Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion Scientific Reports |
| title | Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion |
| title_full | Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion |
| title_fullStr | Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion |
| title_full_unstemmed | Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion |
| title_short | Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion |
| title_sort | cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion |
| url | https://doi.org/10.1038/s41598-020-80014-9 |
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