LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE

Large vessel involvement is one of the hallmarks of Behcet’s disease (BD) but its prevalence varies widely due to ethnic variation or environmental factors. The aim of this study is to find the characteristics of vasculo-Behcet (VB) in Iran. In a cohort of 4769 patients with BD, those with vascular...

Full description

Bibliographic Details
Main Authors: AR. Jamshidi F. Davatchi, A. Nadji, F. Shahram
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2004-08-01
Series:Acta Medica Iranica
Subjects:
Online Access:http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/376.pdf&manuscript_id=376
_version_ 1818213993766977536
author AR. Jamshidi F. Davatchi
A. Nadji
F. Shahram
author_facet AR. Jamshidi F. Davatchi
A. Nadji
F. Shahram
author_sort AR. Jamshidi F. Davatchi
collection DOAJ
description Large vessel involvement is one of the hallmarks of Behcet’s disease (BD) but its prevalence varies widely due to ethnic variation or environmental factors. The aim of this study is to find the characteristics of vasculo-Behcet (VB) in Iran. In a cohort of 4769 patients with BD, those with vascular involvement were selected. Different manifestations of disease were compared with the remaining group of patients. A confidence interval at 95% (CI) was calculated for each item. Vascular involvement was seen in 409 cases (8.6%; CI, 0.8). Venous involvement was seen in 396 cases, deep vein thrombosis in 294 (6.2%; CI, 0.7), superficial phlebitis in 108 (2.3%; CI, 0.4) and large vein thrombosis in 45 (0.9%; CI, 0.3). Arterial involvement was seen in 28 patients (25 aneurysms and 4 thromboses). Thirteen patients showed both arterial and venous involvement. The mean age of the patients with VB was slightly higher (P<0.03), but the disease duration was significantly longer (P<0.0003). VB was more common in men. As the presenting sign, ocular lesions were less frequent in VB (P<0.0006), while skin lesions were over 2 times more common in these cases (P<0.000001). VB was associated with a higher frequency of genital aphthosis, skin involvement, joint manifestations, epididymitis, CNS lesions and GI involvement. The juvenile form was less common in VB (P<0.03). High ESR was more frequent in VB (P=0.000002), but the frequency of false positive VDRL, pathergy phenomenon, HLA-B5 or HLA-B27 showed no significant difference between the two groups. In Iranian patients with BD, vascular involvement is not common and large vessel involvement is rare. It may be sex-related, and is more common in well-established disease with multiple organ involvement and longer disease duration.
first_indexed 2024-12-12T06:13:07Z
format Article
id doaj.art-a48f8f42bfe541e2b9635933cdbcf2f2
institution Directory Open Access Journal
issn 0044-6025
language English
last_indexed 2024-12-12T06:13:07Z
publishDate 2004-08-01
publisher Tehran University of Medical Sciences
record_format Article
series Acta Medica Iranica
spelling doaj.art-a48f8f42bfe541e2b9635933cdbcf2f22022-12-22T00:35:06ZengTehran University of Medical SciencesActa Medica Iranica0044-60252004-08-01423158162LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASEAR. Jamshidi F. DavatchiA. NadjiF. ShahramLarge vessel involvement is one of the hallmarks of Behcet’s disease (BD) but its prevalence varies widely due to ethnic variation or environmental factors. The aim of this study is to find the characteristics of vasculo-Behcet (VB) in Iran. In a cohort of 4769 patients with BD, those with vascular involvement were selected. Different manifestations of disease were compared with the remaining group of patients. A confidence interval at 95% (CI) was calculated for each item. Vascular involvement was seen in 409 cases (8.6%; CI, 0.8). Venous involvement was seen in 396 cases, deep vein thrombosis in 294 (6.2%; CI, 0.7), superficial phlebitis in 108 (2.3%; CI, 0.4) and large vein thrombosis in 45 (0.9%; CI, 0.3). Arterial involvement was seen in 28 patients (25 aneurysms and 4 thromboses). Thirteen patients showed both arterial and venous involvement. The mean age of the patients with VB was slightly higher (P<0.03), but the disease duration was significantly longer (P<0.0003). VB was more common in men. As the presenting sign, ocular lesions were less frequent in VB (P<0.0006), while skin lesions were over 2 times more common in these cases (P<0.000001). VB was associated with a higher frequency of genital aphthosis, skin involvement, joint manifestations, epididymitis, CNS lesions and GI involvement. The juvenile form was less common in VB (P<0.03). High ESR was more frequent in VB (P=0.000002), but the frequency of false positive VDRL, pathergy phenomenon, HLA-B5 or HLA-B27 showed no significant difference between the two groups. In Iranian patients with BD, vascular involvement is not common and large vessel involvement is rare. It may be sex-related, and is more common in well-established disease with multiple organ involvement and longer disease duration.http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/376.pdf&manuscript_id=376Behcet’s diseasevasculo-BehcetDVTphlebitisaneurysm
spellingShingle AR. Jamshidi F. Davatchi
A. Nadji
F. Shahram
LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE
Acta Medica Iranica
Behcet’s disease
vasculo-Behcet
DVT
phlebitis
aneurysm
title LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE
title_full LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE
title_fullStr LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE
title_full_unstemmed LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE
title_short LARGE VESSEL INVOLVEMENT IN BEHCET’S DISEASE
title_sort large vessel involvement in behcet s disease
topic Behcet’s disease
vasculo-Behcet
DVT
phlebitis
aneurysm
url http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/376.pdf&manuscript_id=376
work_keys_str_mv AT arjamshidifdavatchi largevesselinvolvementinbehcetsdisease
AT anadji largevesselinvolvementinbehcetsdisease
AT fshahram largevesselinvolvementinbehcetsdisease