HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors

HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors

Purpose: Human immunodeficiency virus-1 (HIV)-associated neurocognitive disorder (HAND) is a neurodegenerative disease for which there is no available neuroprotective therapy. Viral proteins, such as Tat, have been implicated as agents of neurotoxicity via multiple mechanisms, including effects by d...

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Bibliographic Details
Main Authors: Jeffrey A. Rumbaugh, Muznabanu Bachani, Wenxue Li, Tracy R. Butler, Katherine J. Smith, Mario A. Bianchet, Tongguang Wang, Mark A. Prendergast, Ned Sacktor, Avindra Nath
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Neurobiology of Disease
Subjects:
Neurotoxicity
Neurovirology
Dementia
Neuroprotection
Glutamate
Neutralizing antibodies
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003002

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