Zinc and its role in vitamin D function
Zinc is an essential mineral with an important relationship with vitamin D. Studies have found that reduced blood zinc levels could predict vitamin D deficiency in adolescent girls, while zinc supplementation increased vitamin D levels in postmenopausal women. In vitro studies using human peritoneal...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Physiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665944122000190 |
| _version_ | 1811188528015474688 |
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| author | Ashton Amos Mohammed S. Razzaque |
| author_facet | Ashton Amos Mohammed S. Razzaque |
| author_sort | Ashton Amos |
| collection | DOAJ |
| description | Zinc is an essential mineral with an important relationship with vitamin D. Studies have found that reduced blood zinc levels could predict vitamin D deficiency in adolescent girls, while zinc supplementation increased vitamin D levels in postmenopausal women. In vitro studies using human peritoneal macrophages have found that zinc induced the release of calcitriol (1,25-dihydroxycholecalciferol). Zinc also acts as a cofactor for vitamin D functions, as the transcriptional activity of vitamin D-dependent genes relies on zinc to exert pleiotropic functions, including mineral ion regulation. Vitamin D could also induce zinc transporters to regulate zinc homeostasis. Together, zinc and vitamin D in adequate concentrations help maintain a healthy musculoskeletal system and beyond; however, deficiency in either of these nutrients can result in various disorders affecting almost all body systems. This brief article will focus on the role of zinc in vitamin D functions. |
| first_indexed | 2024-04-11T14:21:28Z |
| format | Article |
| id | doaj.art-a4915699070d4bb7b0558701bce62176 |
| institution | Directory Open Access Journal |
| issn | 2665-9441 |
| language | English |
| last_indexed | 2024-04-11T14:21:28Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Physiology |
| spelling | doaj.art-a4915699070d4bb7b0558701bce621762022-12-22T04:19:04ZengElsevierCurrent Research in Physiology2665-94412022-01-015203207Zinc and its role in vitamin D functionAshton Amos0Mohammed S. Razzaque1Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USACorresponding author..; Department of Pathology, Lake Erie College of Osteopathic Medicine, Erie, PA, USAZinc is an essential mineral with an important relationship with vitamin D. Studies have found that reduced blood zinc levels could predict vitamin D deficiency in adolescent girls, while zinc supplementation increased vitamin D levels in postmenopausal women. In vitro studies using human peritoneal macrophages have found that zinc induced the release of calcitriol (1,25-dihydroxycholecalciferol). Zinc also acts as a cofactor for vitamin D functions, as the transcriptional activity of vitamin D-dependent genes relies on zinc to exert pleiotropic functions, including mineral ion regulation. Vitamin D could also induce zinc transporters to regulate zinc homeostasis. Together, zinc and vitamin D in adequate concentrations help maintain a healthy musculoskeletal system and beyond; however, deficiency in either of these nutrients can result in various disorders affecting almost all body systems. This brief article will focus on the role of zinc in vitamin D functions.http://www.sciencedirect.com/science/article/pii/S2665944122000190ZincVitamin DSourcesInteractionsDeficiency |
| spellingShingle | Ashton Amos Mohammed S. Razzaque Zinc and its role in vitamin D function Current Research in Physiology Zinc Vitamin D Sources Interactions Deficiency |
| title | Zinc and its role in vitamin D function |
| title_full | Zinc and its role in vitamin D function |
| title_fullStr | Zinc and its role in vitamin D function |
| title_full_unstemmed | Zinc and its role in vitamin D function |
| title_short | Zinc and its role in vitamin D function |
| title_sort | zinc and its role in vitamin d function |
| topic | Zinc Vitamin D Sources Interactions Deficiency |
| url | http://www.sciencedirect.com/science/article/pii/S2665944122000190 |
| work_keys_str_mv | AT ashtonamos zincanditsroleinvitamindfunction AT mohammedsrazzaque zincanditsroleinvitamindfunction |