Liver organoids and their application in liver cancer research
Liver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods. Looking for an effective platform for liver cancer study and drug screening is urgent and important. Traditi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Regenerative Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235232042300144X |
| _version_ | 1797268993286864896 |
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| author | Xinyu Song Kaifei Hou Hongyan Zhou Jingyi Yang Ting Cao Jiayu Zhang |
| author_facet | Xinyu Song Kaifei Hou Hongyan Zhou Jingyi Yang Ting Cao Jiayu Zhang |
| author_sort | Xinyu Song |
| collection | DOAJ |
| description | Liver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods. Looking for an effective platform for liver cancer study and drug screening is urgent and important. Traditional analytical methods for liver disease studies mainly rely on the 2D cell culture and animal experiments, which both cannot fully recapitulate physiological and pathological processes of human liver. For example, cell culture can only show basic functions of cells in vitro, while animal models always hold the problem of species divergence. The organoids, a 3D invitro culture system emerged in recent years, is a cell-bound body with different cell types and has partial tissue functions. The organoid technology can reveal the growth state, structure, function and characteristics of the tissue or organ, and plays an important role in reconstructing invitro experimental models that can truly simulate the human liver. In this paper, we will give a brief introduction of liver organoids and review their applications in liver cancer research, especially in liver cancer pathogenesis, drug screening, precision medicine, regenerative medicine, and other fields. We have also discussed advantages and disadvantages of organoids, as well as future directions and perspectives towards liver organoids. |
| first_indexed | 2024-03-08T19:41:44Z |
| format | Article |
| id | doaj.art-a4915f9e0bff4427b8e29b665d9c54a7 |
| institution | Directory Open Access Journal |
| issn | 2352-3204 |
| language | English |
| last_indexed | 2024-04-25T01:41:18Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj.art-a4915f9e0bff4427b8e29b665d9c54a72024-03-08T05:18:48ZengElsevierRegenerative Therapy2352-32042024-03-0125128137Liver organoids and their application in liver cancer researchXinyu Song0Kaifei Hou1Hongyan Zhou2Jingyi Yang3Ting Cao4Jiayu Zhang5Binzhou Medical University, 264003 Yantai, Shandong, ChinaBinzhou Medical University, 264003 Yantai, Shandong, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, 250300 Jinan, Shandong, ChinaBinzhou Medical University, 264003 Yantai, Shandong, ChinaThe First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, Zhejiang, China; Corresponding author.Corresponding author.; Binzhou Medical University, 264003 Yantai, Shandong, China; School of Pharmacy, Shandong University of Traditional Chinese Medicine, 250300 Jinan, Shandong, China; The First Affiliated Hospital, School of Medicine, Zhejiang University, 310003 Hangzhou, Zhejiang, China; School of Traditional Chinese Medicine, Binzhou Medical University, 264003 Yantai, Shandong, ChinaLiver cancer, a common and intractable liver-related disease, is a malignant tumor with a high morbidity, which needs a high treatment cost but still lacks perfect clinical treatment methods. Looking for an effective platform for liver cancer study and drug screening is urgent and important. Traditional analytical methods for liver disease studies mainly rely on the 2D cell culture and animal experiments, which both cannot fully recapitulate physiological and pathological processes of human liver. For example, cell culture can only show basic functions of cells in vitro, while animal models always hold the problem of species divergence. The organoids, a 3D invitro culture system emerged in recent years, is a cell-bound body with different cell types and has partial tissue functions. The organoid technology can reveal the growth state, structure, function and characteristics of the tissue or organ, and plays an important role in reconstructing invitro experimental models that can truly simulate the human liver. In this paper, we will give a brief introduction of liver organoids and review their applications in liver cancer research, especially in liver cancer pathogenesis, drug screening, precision medicine, regenerative medicine, and other fields. We have also discussed advantages and disadvantages of organoids, as well as future directions and perspectives towards liver organoids.http://www.sciencedirect.com/science/article/pii/S235232042300144XLiver cancerOrganoidsPathogenesisDrug screeningPrecision medicine |
| spellingShingle | Xinyu Song Kaifei Hou Hongyan Zhou Jingyi Yang Ting Cao Jiayu Zhang Liver organoids and their application in liver cancer research Regenerative Therapy Liver cancer Organoids Pathogenesis Drug screening Precision medicine |
| title | Liver organoids and their application in liver cancer research |
| title_full | Liver organoids and their application in liver cancer research |
| title_fullStr | Liver organoids and their application in liver cancer research |
| title_full_unstemmed | Liver organoids and their application in liver cancer research |
| title_short | Liver organoids and their application in liver cancer research |
| title_sort | liver organoids and their application in liver cancer research |
| topic | Liver cancer Organoids Pathogenesis Drug screening Precision medicine |
| url | http://www.sciencedirect.com/science/article/pii/S235232042300144X |
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