Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review
Ethnopharmacological relevance:Alchornea laxiflora (Benth.) Pax & K. Hoffm. (Euphorbiaceae) is an important traditional medicinal plant grown in tropical Africa. The stem, leaves, and root have been widely used in the folk medicine systems in Nigeria, Cameroon, South Africa, and Ghana to tre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.958453/full |
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| author | Nem Kumar Jain Nem Kumar Jain Mukul Tailang Santosh Kumar Balakumar Chandrasekaran Balakumar Chandrasekaran Yahia Alghazwani Harish C. Chandramoorthy Harish C. Chandramoorthy Ashish Kumar Hemali Deshpande Pranay Wal Manickam Balamurugan Kumarappan Chidambaram |
| author_facet | Nem Kumar Jain Nem Kumar Jain Mukul Tailang Santosh Kumar Balakumar Chandrasekaran Balakumar Chandrasekaran Yahia Alghazwani Harish C. Chandramoorthy Harish C. Chandramoorthy Ashish Kumar Hemali Deshpande Pranay Wal Manickam Balamurugan Kumarappan Chidambaram |
| author_sort | Nem Kumar Jain |
| collection | DOAJ |
| description | Ethnopharmacological relevance:Alchornea laxiflora (Benth.) Pax & K. Hoffm. (Euphorbiaceae) is an important traditional medicinal plant grown in tropical Africa. The stem, leaves, and root have been widely used in the folk medicine systems in Nigeria, Cameroon, South Africa, and Ghana to treat various ailments, including inflammatory, infectious, and central nervous system disorders, such as anxiety and epilepsy.Material and methods: The scientific name of the plant was validated using the “The Plant List,” “Kew Royal Botanic Gardens,” and Tropicos Nomenclatural databases. The literature search on A. laxiflora was performed using electronic search engines and databases such as Google scholar, ScienceDirect, PubMed, AJOL, Scopus, and Mendeley.Results: To the best of our knowledge, no specific and detailed review has been reported on A. laxiflora. Consequently, this review provides an up-to-date systematic presentation on ethnobotany, phytoconstituents, pharmacological activities, and toxicity profiles of A. laxiflora. Phytochemical investigations disclosed the presence of important compounds, such as alkaloids, flavonoids, phenolics, terpenoids, and fatty acids. Furthermore, various pharmacological activities and traditional uses reported for this botanical drug were discussed comprehensively.Conclusion: This systemic review presents the current status and perspectives of A. laxiflora as a potential therapeutic modality that would assist future researchers in exploring this African botanical drug as a source of novel drug candidates for varied diseases. |
| first_indexed | 2024-04-11T14:44:16Z |
| format | Article |
| id | doaj.art-a49173a36e74456e84f10c4adc363690 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T14:44:16Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a49173a36e74456e84f10c4adc3636902022-12-22T04:17:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-12-011310.3389/fphar.2022.958453958453Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic reviewNem Kumar Jain0Nem Kumar Jain1Mukul Tailang2Santosh Kumar3Balakumar Chandrasekaran4Balakumar Chandrasekaran5Yahia Alghazwani6Harish C. Chandramoorthy7Harish C. Chandramoorthy8Ashish Kumar9Hemali Deshpande10Pranay Wal11Manickam Balamurugan12Kumarappan Chidambaram13School of Pharmacy, ITM University, Gwalior, Gwalior, Madhya Pradesh, IndiaSchool of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, IndiaSchool of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, IndiaSchool of Sciences, ITM University, Gwalior, Gwalior, Madhya Pradesh, IndiaSchool of Pharmacy, ITM University, Gwalior, Gwalior, Madhya Pradesh, IndiaFaculty of Pharmacy, Philadelphia University, Amman, JordanDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaDepartment of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi ArabiaCenter for Stem Cell Research, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Microbiology and Clinical Parasitology, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Anatomy, College of Medicine, King Khalid University, Abha, Saudi ArabiaDepartment of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, India0College of Pharmacy and Nursing, University of Nizwa, Nizwa, OmanDepartment of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaEthnopharmacological relevance:Alchornea laxiflora (Benth.) Pax & K. Hoffm. (Euphorbiaceae) is an important traditional medicinal plant grown in tropical Africa. The stem, leaves, and root have been widely used in the folk medicine systems in Nigeria, Cameroon, South Africa, and Ghana to treat various ailments, including inflammatory, infectious, and central nervous system disorders, such as anxiety and epilepsy.Material and methods: The scientific name of the plant was validated using the “The Plant List,” “Kew Royal Botanic Gardens,” and Tropicos Nomenclatural databases. The literature search on A. laxiflora was performed using electronic search engines and databases such as Google scholar, ScienceDirect, PubMed, AJOL, Scopus, and Mendeley.Results: To the best of our knowledge, no specific and detailed review has been reported on A. laxiflora. Consequently, this review provides an up-to-date systematic presentation on ethnobotany, phytoconstituents, pharmacological activities, and toxicity profiles of A. laxiflora. Phytochemical investigations disclosed the presence of important compounds, such as alkaloids, flavonoids, phenolics, terpenoids, and fatty acids. Furthermore, various pharmacological activities and traditional uses reported for this botanical drug were discussed comprehensively.Conclusion: This systemic review presents the current status and perspectives of A. laxiflora as a potential therapeutic modality that would assist future researchers in exploring this African botanical drug as a source of novel drug candidates for varied diseases.https://www.frontiersin.org/articles/10.3389/fphar.2022.958453/fullAlchornea laxifloraethnopharmacologyAfrican plantstraditional medicinephytochemistrypharmacology |
| spellingShingle | Nem Kumar Jain Nem Kumar Jain Mukul Tailang Santosh Kumar Balakumar Chandrasekaran Balakumar Chandrasekaran Yahia Alghazwani Harish C. Chandramoorthy Harish C. Chandramoorthy Ashish Kumar Hemali Deshpande Pranay Wal Manickam Balamurugan Kumarappan Chidambaram Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review Frontiers in Pharmacology Alchornea laxiflora ethnopharmacology African plants traditional medicine phytochemistry pharmacology |
| title | Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review |
| title_full | Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review |
| title_fullStr | Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review |
| title_full_unstemmed | Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review |
| title_short | Appraising the therapeutical potentials of Alchornea laxiflora (Benth.) Pax & K. Hoffm., an underexplored medicinal herb: A systematic review |
| title_sort | appraising the therapeutical potentials of alchornea laxiflora benth pax k hoffm an underexplored medicinal herb a systematic review |
| topic | Alchornea laxiflora ethnopharmacology African plants traditional medicine phytochemistry pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.958453/full |
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