Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic
The Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB).In this work we present how we 1) adapted the...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222003382 |
| _version_ | 1811304310160490496 |
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| author | Ludovica Griffanti Grace Gillis M. Clare O'Donoghue Jasmine Blane Pieter M. Pretorius Robert Mitchell Nicola Aikin Karen Lindsay Jon Campbell Juliet Semple Fidel Alfaro-Almagro Stephen M. Smith Karla L. Miller Lola Martos Vanessa Raymont Clare E. Mackay |
| author_facet | Ludovica Griffanti Grace Gillis M. Clare O'Donoghue Jasmine Blane Pieter M. Pretorius Robert Mitchell Nicola Aikin Karen Lindsay Jon Campbell Juliet Semple Fidel Alfaro-Almagro Stephen M. Smith Karla L. Miller Lola Martos Vanessa Raymont Clare E. Mackay |
| author_sort | Ludovica Griffanti |
| collection | DOAJ |
| description | The Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB).In this work we present how we 1) adapted the UKB MRI acquisition protocol to be suitable for memory clinic patients, 2) modified the imaging analysis pipeline to extract measures that are in line with radiology reports and 3) explored the alignment of measures from BHC patients to the largest brain MRI study in the world (ultimately 100,000 participants).Adaptations of the UKB acquisition protocol for BHC patients include dividing the scan into core and optional sequences (i.e., additional imaging modalities) to improve patients’ tolerance for the MRI assessment. We adapted the UKB structural MRI analysis pipeline to take into account the characteristics of a memory clinic population (e.g., high amount of white matter hyperintensities and hippocampal atrophy). We then compared the imaging derived phenotypes (IDPs) extracted from the structural scans to visual ratings from radiology reports, non-imaging factors (age, cognition) and to reference distributions derived from UKB data.Of the first 108 BHC attendees (August 2020-November 2021), 92.5 % completed the clinical scans, 88.0 % consented to use of data for research, and 43.5 % completed the additional research sequences, demonstrating that the protocol is well tolerated. The high rates of consent to research makes this a valuable real-world quality research dataset routinely captured in a clinical service. Modified tissue-type segmentation with lesion masking greatly improved grey matter volume estimation. CSF-masking marginally improved hippocampal segmentation. The IDPs were in line with radiology reports and showed significant associations with age and cognitive performance, in line with the literature. Due to the age difference between memory clinic patients of the BHC (age range 65–101 years, average 78.3 years) and UKB participants (44–82 years, average 64 years), additional scans on elderly healthy controls are needed to improve reference distributions. Current and future work aims to integrate automated quantitative measures in the radiology reports and evaluate their clinical utility. |
| first_indexed | 2024-04-13T08:03:49Z |
| format | Article |
| id | doaj.art-a492c9e7a85948e1ba47c3d75ecde581 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T08:03:49Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-a492c9e7a85948e1ba47c3d75ecde5812022-12-22T02:55:13ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103273Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health ClinicLudovica Griffanti0Grace Gillis1M. Clare O'Donoghue2Jasmine Blane3Pieter M. Pretorius4Robert Mitchell5Nicola Aikin6Karen Lindsay7Jon Campbell8Juliet Semple9Fidel Alfaro-Almagro10Stephen M. Smith11Karla L. Miller12Lola Martos13Vanessa Raymont14Clare E. Mackay15Department of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United Kingdom; Corresponding author at: Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX.Department of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Oxford University Hospitals NHS Trust, Oxford, United KingdomOxford Health NHS Foundation Trust, Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomNuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Oxford Health NHS Foundation Trust, Oxford, United KingdomDepartment of Psychiatry, University of Oxford, United Kingdom; Wellcome Centre for Integrative Neuroimaging, University of Oxford, United KingdomThe Oxford Brain Health Clinic (BHC) is a joint clinical-research service that provides memory clinic patients and clinicians access to high-quality assessments not routinely available, including brain MRI aligned with the UK Biobank imaging study (UKB).In this work we present how we 1) adapted the UKB MRI acquisition protocol to be suitable for memory clinic patients, 2) modified the imaging analysis pipeline to extract measures that are in line with radiology reports and 3) explored the alignment of measures from BHC patients to the largest brain MRI study in the world (ultimately 100,000 participants).Adaptations of the UKB acquisition protocol for BHC patients include dividing the scan into core and optional sequences (i.e., additional imaging modalities) to improve patients’ tolerance for the MRI assessment. We adapted the UKB structural MRI analysis pipeline to take into account the characteristics of a memory clinic population (e.g., high amount of white matter hyperintensities and hippocampal atrophy). We then compared the imaging derived phenotypes (IDPs) extracted from the structural scans to visual ratings from radiology reports, non-imaging factors (age, cognition) and to reference distributions derived from UKB data.Of the first 108 BHC attendees (August 2020-November 2021), 92.5 % completed the clinical scans, 88.0 % consented to use of data for research, and 43.5 % completed the additional research sequences, demonstrating that the protocol is well tolerated. The high rates of consent to research makes this a valuable real-world quality research dataset routinely captured in a clinical service. Modified tissue-type segmentation with lesion masking greatly improved grey matter volume estimation. CSF-masking marginally improved hippocampal segmentation. The IDPs were in line with radiology reports and showed significant associations with age and cognitive performance, in line with the literature. Due to the age difference between memory clinic patients of the BHC (age range 65–101 years, average 78.3 years) and UKB participants (44–82 years, average 64 years), additional scans on elderly healthy controls are needed to improve reference distributions. Current and future work aims to integrate automated quantitative measures in the radiology reports and evaluate their clinical utility.http://www.sciencedirect.com/science/article/pii/S2213158222003382UK Biobankstructural MRIMagnetic resonance imagingMemory clinicDementia |
| spellingShingle | Ludovica Griffanti Grace Gillis M. Clare O'Donoghue Jasmine Blane Pieter M. Pretorius Robert Mitchell Nicola Aikin Karen Lindsay Jon Campbell Juliet Semple Fidel Alfaro-Almagro Stephen M. Smith Karla L. Miller Lola Martos Vanessa Raymont Clare E. Mackay Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic NeuroImage: Clinical UK Biobank structural MRI Magnetic resonance imaging Memory clinic Dementia |
| title | Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic |
| title_full | Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic |
| title_fullStr | Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic |
| title_full_unstemmed | Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic |
| title_short | Adapting UK Biobank imaging for use in a routine memory clinic setting: The Oxford Brain Health Clinic |
| title_sort | adapting uk biobank imaging for use in a routine memory clinic setting the oxford brain health clinic |
| topic | UK Biobank structural MRI Magnetic resonance imaging Memory clinic Dementia |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222003382 |
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