Regional specialization of the tongue revealed by gustatory ganglion imaging
Summary: Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of the jugular/nodose/petrosal ganglion complex. Here, we use in vivo calcium imaging in mice to compare the encoding of taste informatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222019733 |
| _version_ | 1811292246017835008 |
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| author | Bryan E. Fowler Jiahao Ye Saima Humayun Hojoon Lee Lindsey J. Macpherson |
| author_facet | Bryan E. Fowler Jiahao Ye Saima Humayun Hojoon Lee Lindsey J. Macpherson |
| author_sort | Bryan E. Fowler |
| collection | DOAJ |
| description | Summary: Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of the jugular/nodose/petrosal ganglion complex. Here, we use in vivo calcium imaging in mice to compare the encoding of taste information in the geniculate and petrosal ganglia, at single-neuron resolution. Our data support an anterior/posterior specialization of taste information coding from the tongue to the ganglia, with petrosal neurons more responsive to umami or bitter and less responsive to sweet or salty stimuli than geniculate neurons. We found that umami (50 mM MPG + 1 mM IMP) promotes salivation when applied to the posterior, but not anterior, tongue. This suggests a functional taste map of the mammalian tongue where the anterior and posterior taste pathways are differentially responsive to specific taste qualities, and differentially regulate downstream physiological functions of taste, such as promoting salivation. |
| first_indexed | 2024-04-13T04:42:32Z |
| format | Article |
| id | doaj.art-a494c70365064939bedd63ff4e4e7885 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-13T04:42:32Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-a494c70365064939bedd63ff4e4e78852022-12-22T03:01:57ZengElsevieriScience2589-00422022-12-012512105700Regional specialization of the tongue revealed by gustatory ganglion imagingBryan E. Fowler0Jiahao Ye1Saima Humayun2Hojoon Lee3Lindsey J. Macpherson4Department of Neuroscience Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, TX, USADepartment of Neurobiology, Northwestern University, Evanston, IL, USADepartment of Neuroscience Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, TX, USADepartment of Neurobiology, Northwestern University, Evanston, IL, USADepartment of Neuroscience Developmental and Regenerative Biology, The University of Texas at San Antonio, San Antonio, TX, USA; Brain Health Consortium, The University of Texas at San Antonio, San Antonio, TX, USA; Corresponding authorSummary: Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of the jugular/nodose/petrosal ganglion complex. Here, we use in vivo calcium imaging in mice to compare the encoding of taste information in the geniculate and petrosal ganglia, at single-neuron resolution. Our data support an anterior/posterior specialization of taste information coding from the tongue to the ganglia, with petrosal neurons more responsive to umami or bitter and less responsive to sweet or salty stimuli than geniculate neurons. We found that umami (50 mM MPG + 1 mM IMP) promotes salivation when applied to the posterior, but not anterior, tongue. This suggests a functional taste map of the mammalian tongue where the anterior and posterior taste pathways are differentially responsive to specific taste qualities, and differentially regulate downstream physiological functions of taste, such as promoting salivation.http://www.sciencedirect.com/science/article/pii/S2589004222019733Cellular neurosciencesensory neuroscience |
| spellingShingle | Bryan E. Fowler Jiahao Ye Saima Humayun Hojoon Lee Lindsey J. Macpherson Regional specialization of the tongue revealed by gustatory ganglion imaging iScience Cellular neuroscience sensory neuroscience |
| title | Regional specialization of the tongue revealed by gustatory ganglion imaging |
| title_full | Regional specialization of the tongue revealed by gustatory ganglion imaging |
| title_fullStr | Regional specialization of the tongue revealed by gustatory ganglion imaging |
| title_full_unstemmed | Regional specialization of the tongue revealed by gustatory ganglion imaging |
| title_short | Regional specialization of the tongue revealed by gustatory ganglion imaging |
| title_sort | regional specialization of the tongue revealed by gustatory ganglion imaging |
| topic | Cellular neuroscience sensory neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222019733 |
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