Optimization of an Inclusion Body-Based Production of the Influenza Virus Neuraminidase in <i>Escherichia coli</i>

Optimization of an Inclusion Body-Based Production of the Influenza Virus Neuraminidase in <i>Escherichia coli</i>

Neuraminidase (NA), as an important protein of influenza virus, represents a promising target for the development of new antiviral agents for the treatment and prevention of influenza A and B. Bacterial host strain <i>Escherichia coli</i> BL21 (DE3)pLysS containing the NA gene of the H1N...

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Bibliographic Details
Main Authors: Sabina Lipničanová, Barbora Legerská, Daniela Chmelová, Miroslav Ondrejovič, Stanislav Miertuš
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomolecules
Subjects:
neuraminidase
inclusion body
recombinant protein
expression
optimization
response surface methodology
Online Access:https://www.mdpi.com/2218-273X/12/2/331

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