Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats
Previous study showed that sea cucumber and spirulina had an antioxidant activity and antihyperglycemic activity. Sea cucumbers contain a cell growth factor that is useful in wound healing. This research aimed to determine the activity of sea cucumber and spirulina in decreasing the fasting blood gl...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/11/bioconf_icmmbt2023_02011.pdf |
| _version_ | 1797299510748119040 |
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| author | Susanto Hendra Safithri Mega Tarman Kustiariyah Setyaningsih Iriani |
| author_facet | Susanto Hendra Safithri Mega Tarman Kustiariyah Setyaningsih Iriani |
| author_sort | Susanto Hendra |
| collection | DOAJ |
| description | Previous study showed that sea cucumber and spirulina had an antioxidant activity and antihyperglycemic activity. Sea cucumbers contain a cell growth factor that is useful in wound healing. This research aimed to determine the activity of sea cucumber and spirulina in decreasing the fasting blood glucose and wound healing process in streptozotocin-induced diabetic rats. The antihyperglycemic activity and wound healing test were done to experimental rats that have been conditioned with diabetic wound. 2840 mg/kg body weight of liquid preparation of sea cucumber methanol extract and 81 mg/kg body weight of spirulina extract were given through oral gavage and sea cucumber methanol extract was given topically once a day. The results showed that group of golden sea cucumber orally-topically had the best antihyperglycemic activity with the highest percentage reduction in blood glucose level while group of golden sea cucumber topically-spirulina orally had the best wound healing effect with the highest percentage of wound healing. |
| first_indexed | 2024-03-07T22:51:39Z |
| format | Article |
| id | doaj.art-a495f04fc64549efa88bce876c2a2a6b |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-03-07T22:51:39Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-a495f04fc64549efa88bce876c2a2a6b2024-02-23T10:17:35ZengEDP SciencesBIO Web of Conferences2117-44582024-01-01920201110.1051/bioconf/20249202011bioconf_icmmbt2023_02011Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic RatsSusanto Hendra0Safithri Mega1Tarman Kustiariyah2Setyaningsih Iriani3Departement of Biochemisty, Faculty of Mathematics and Natural Sciences, Bogor Agricultural UniversityDepartement of Biochemisty, Faculty of Mathematics and Natural Sciences, Bogor Agricultural UniversityDepartement of Aquatic Products Technology, Faculty of Fisheries and Marine Sciences, Bogor Agricultural UniversityDepartement of Aquatic Products Technology, Faculty of Fisheries and Marine Sciences, Bogor Agricultural UniversityPrevious study showed that sea cucumber and spirulina had an antioxidant activity and antihyperglycemic activity. Sea cucumbers contain a cell growth factor that is useful in wound healing. This research aimed to determine the activity of sea cucumber and spirulina in decreasing the fasting blood glucose and wound healing process in streptozotocin-induced diabetic rats. The antihyperglycemic activity and wound healing test were done to experimental rats that have been conditioned with diabetic wound. 2840 mg/kg body weight of liquid preparation of sea cucumber methanol extract and 81 mg/kg body weight of spirulina extract were given through oral gavage and sea cucumber methanol extract was given topically once a day. The results showed that group of golden sea cucumber orally-topically had the best antihyperglycemic activity with the highest percentage reduction in blood glucose level while group of golden sea cucumber topically-spirulina orally had the best wound healing effect with the highest percentage of wound healing.https://www.bio-conferences.org/articles/bioconf/pdf/2024/11/bioconf_icmmbt2023_02011.pdf |
| spellingShingle | Susanto Hendra Safithri Mega Tarman Kustiariyah Setyaningsih Iriani Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats BIO Web of Conferences |
| title | Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats |
| title_full | Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats |
| title_fullStr | Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats |
| title_full_unstemmed | Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats |
| title_short | Activity of Sea Cucumber and Spirulina in Wound Healing and Blood Glucose Decreasing in Streptozotocin- Induced Diabetic Rats |
| title_sort | activity of sea cucumber and spirulina in wound healing and blood glucose decreasing in streptozotocin induced diabetic rats |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/11/bioconf_icmmbt2023_02011.pdf |
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