The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination

The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination

HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. HMGB1 is normally localized to the nucleus, where it acts as a chromatin associated non-histone binding protein. In contrast, extracellular HMGB1 is an alarmin released by stressed cells to act as a danger associated molecular patt...

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Bibliographic Details
Main Authors: Megan E. Rouillard, Jingwen Hu, Pearl A. Sutter, Hee Won Kim, Jeffrey K. Huang, Stephen J. Crocker
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cellular senescence
myelin
multiple sclerosis
lysolecithin (LPC)
microglia
TLR2
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.833186/full

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