Communication at the host-pathogen interface
The oral cavity represents a finely balanced ecosystem in which a plethora of bacterial species lives in complex communities known as biofilms. To cohabitate efficiently, bacteria within these biofilms have evolved intricate systems of communication, such as quorum sensing, cooperation or competitio...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Journal of Oral Microbiology |
| Online Access: | http://dx.doi.org/10.1080/20002297.2017.1325269 |
| _version_ | 1819071559619313664 |
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| author | Sarah A. Kuehne |
| author_facet | Sarah A. Kuehne |
| author_sort | Sarah A. Kuehne |
| collection | DOAJ |
| description | The oral cavity represents a finely balanced ecosystem in which a plethora of bacterial species lives in complex communities known as biofilms. To cohabitate efficiently, bacteria within these biofilms have evolved intricate systems of communication, such as quorum sensing, cooperation or competition, involving signaling, sharing of resources and/or metabolic activities. Dysbiosis can develop and lead to periodontitis, the most common human chronic inflammatory disease. Briefly, Streptococci, recognised as early colonisers, are followed by Fusobacterium nucleatum, known as a ‘bridging organism’. The latter interacts with multiple bacterial species, facilitating their adherence, leading to formation of a disease-associated biofilm. Specifically, bacteria of the “red complex” (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) and Aggregatibacter actinomycetemcomitans emerge to prominence within the periodontal pocket. While this aggregation of different species is well documented, their means of communication and in particular their mechanisms of recruitment are less well understood. The role of F. nucleatum is of particular interest as it interacts with multiple species in the oral biofilm and modulates progression from health to disease. Its role in controlling oral health could be pivotal. Here we are investigating the impact of F. nucleatum in establishing the disease-associated biofilm by analysing bacterial cell-cell communication and bacteria-host interactions. |
| first_indexed | 2024-12-21T17:23:46Z |
| format | Article |
| id | doaj.art-a49a824a4df240fd912b92d26d1d7b70 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-21T17:23:46Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-a49a824a4df240fd912b92d26d1d7b702022-12-21T18:56:06ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972017-05-019010.1080/20002297.2017.13252691325269Communication at the host-pathogen interfaceSarah A. Kuehne0University of BirminghamThe oral cavity represents a finely balanced ecosystem in which a plethora of bacterial species lives in complex communities known as biofilms. To cohabitate efficiently, bacteria within these biofilms have evolved intricate systems of communication, such as quorum sensing, cooperation or competition, involving signaling, sharing of resources and/or metabolic activities. Dysbiosis can develop and lead to periodontitis, the most common human chronic inflammatory disease. Briefly, Streptococci, recognised as early colonisers, are followed by Fusobacterium nucleatum, known as a ‘bridging organism’. The latter interacts with multiple bacterial species, facilitating their adherence, leading to formation of a disease-associated biofilm. Specifically, bacteria of the “red complex” (Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) and Aggregatibacter actinomycetemcomitans emerge to prominence within the periodontal pocket. While this aggregation of different species is well documented, their means of communication and in particular their mechanisms of recruitment are less well understood. The role of F. nucleatum is of particular interest as it interacts with multiple species in the oral biofilm and modulates progression from health to disease. Its role in controlling oral health could be pivotal. Here we are investigating the impact of F. nucleatum in establishing the disease-associated biofilm by analysing bacterial cell-cell communication and bacteria-host interactions.http://dx.doi.org/10.1080/20002297.2017.1325269 |
| spellingShingle | Sarah A. Kuehne Communication at the host-pathogen interface Journal of Oral Microbiology |
| title | Communication at the host-pathogen interface |
| title_full | Communication at the host-pathogen interface |
| title_fullStr | Communication at the host-pathogen interface |
| title_full_unstemmed | Communication at the host-pathogen interface |
| title_short | Communication at the host-pathogen interface |
| title_sort | communication at the host pathogen interface |
| url | http://dx.doi.org/10.1080/20002297.2017.1325269 |
| work_keys_str_mv | AT sarahakuehne communicationatthehostpathogeninterface |